A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast
Аутори
Shin, Wook-Geun![](/themes/MirageVinar/images/orcid.png)
Sakata, Dousatsu
Lampe, Nathanael
Belov, Oleg
Tran, Ngoc Hoang
![](/themes/MirageVinar/images/orcid.png)
Petrović, Ivan M.
![](/themes/MirageVinar/images/orcid.png)
Ristić-Fira, Aleksandra
![](/themes/MirageVinar/images/orcid.png)
Đorđević, Miloš
![](/themes/MirageVinar/images/orcid.png)
Bernal, Mario A.
![](/themes/MirageVinar/images/orcid.png)
Bordage, Marie-Claude
Francis, Ziad
![](/themes/MirageVinar/images/orcid.png)
Kyriakou, Ioanna
![](/themes/MirageVinar/images/orcid.png)
Perrot, Yann
Sasaki, Takashi
![](/themes/MirageVinar/images/orcid.png)
Villagrasa, Carmen
Guatelli, Susanna
Breton, Vincent
Emfietzoglou, Dimitris
Incerti, Sebastien
![](/themes/MirageVinar/images/orcid.png)
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. T...he resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application “molecularDNA”, an example for users of Geant4-DNA, will soon be distributed through Geant4.
Кључне речи:
DNA damage / Geant4-DNA / Monte Carlo track structure simulationИзвор:
Cancers, 2021, 13, 19, 4940-Финансирање / пројекти:
- Ministry of Education, Science & Technological Development, Serbia
- European Space Agency[4000126645/19/NL/BW, 4000132935/21/NL/CRS]
- FAPESP [2011/51594-2, 2015/21873-8, 2018/15316-7, 2020/08647-7]
- CNRS PICS, France-Serbia [8070]
- CNPQ [306298/2018-0]
DOI: 10.3390/cancers13194940
ISSN: 2072-6694
PubMed: 34638425
WoS: 000708176900001
Scopus: 2-s2.0-85116003494
Институција/група
VinčaTY - JOUR AU - Shin, Wook-Geun AU - Sakata, Dousatsu AU - Lampe, Nathanael AU - Belov, Oleg AU - Tran, Ngoc Hoang AU - Petrović, Ivan M. AU - Ristić-Fira, Aleksandra AU - Đorđević, Miloš AU - Bernal, Mario A. AU - Bordage, Marie-Claude AU - Francis, Ziad AU - Kyriakou, Ioanna AU - Perrot, Yann AU - Sasaki, Takashi AU - Villagrasa, Carmen AU - Guatelli, Susanna AU - Breton, Vincent AU - Emfietzoglou, Dimitris AU - Incerti, Sebastien PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9961 AB - Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application “molecularDNA”, an example for users of Geant4-DNA, will soon be distributed through Geant4. T2 - Cancers T2 - Cancers T1 - A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast VL - 13 IS - 19 SP - 4940 DO - 10.3390/cancers13194940 ER -
@article{ author = "Shin, Wook-Geun and Sakata, Dousatsu and Lampe, Nathanael and Belov, Oleg and Tran, Ngoc Hoang and Petrović, Ivan M. and Ristić-Fira, Aleksandra and Đorđević, Miloš and Bernal, Mario A. and Bordage, Marie-Claude and Francis, Ziad and Kyriakou, Ioanna and Perrot, Yann and Sasaki, Takashi and Villagrasa, Carmen and Guatelli, Susanna and Breton, Vincent and Emfietzoglou, Dimitris and Incerti, Sebastien", year = "2021", abstract = "Accurately modeling the radiobiological mechanisms responsible for the induction of DNA damage remains a major scientific challenge, particularly for understanding the effects of low doses of ionizing radiation on living beings, such as the induction of carcinogenesis. A computational approach based on the Monte Carlo technique to simulate track structures in a biological medium is currently the most reliable method for calculating the early effects induced by ionizing radiation on DNA, the primary cellular target of such effects. The Geant4-DNA Monte Carlo toolkit can simulate not only the physical, but also the physico-chemical and chemical stages of water radiolysis. These stages can be combined with simplified geometric models of biological targets, such as DNA, to assess direct and indirect early DNA damage. In this study, DNA damage induced in a human fibroblast cell was evaluated using Geant4-DNA as a function of incident particle type (gammas, protons, and alphas) and energy. The resulting double-strand break yields as a function of linear energy transfer closely reproduced recent experimental data. Other quantities, such as fragment length distribution, scavengeable damage fraction, and time evolution of damage within an analytical repair model also supported the plausibility of predicting DNA damage using Geant4-DNA.The complete simulation chain application “molecularDNA”, an example for users of Geant4-DNA, will soon be distributed through Geant4.", journal = "Cancers, Cancers", title = "A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast", volume = "13", number = "19", pages = "4940", doi = "10.3390/cancers13194940" }
Shin, W., Sakata, D., Lampe, N., Belov, O., Tran, N. H., Petrović, I. M., Ristić-Fira, A., Đorđević, M., Bernal, M. A., Bordage, M., Francis, Z., Kyriakou, I., Perrot, Y., Sasaki, T., Villagrasa, C., Guatelli, S., Breton, V., Emfietzoglou, D.,& Incerti, S.. (2021). A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. in Cancers, 13(19), 4940. https://doi.org/10.3390/cancers13194940
Shin W, Sakata D, Lampe N, Belov O, Tran NH, Petrović IM, Ristić-Fira A, Đorđević M, Bernal MA, Bordage M, Francis Z, Kyriakou I, Perrot Y, Sasaki T, Villagrasa C, Guatelli S, Breton V, Emfietzoglou D, Incerti S. A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast. in Cancers. 2021;13(19):4940. doi:10.3390/cancers13194940 .
Shin, Wook-Geun, Sakata, Dousatsu, Lampe, Nathanael, Belov, Oleg, Tran, Ngoc Hoang, Petrović, Ivan M., Ristić-Fira, Aleksandra, Đorđević, Miloš, Bernal, Mario A., Bordage, Marie-Claude, Francis, Ziad, Kyriakou, Ioanna, Perrot, Yann, Sasaki, Takashi, Villagrasa, Carmen, Guatelli, Susanna, Breton, Vincent, Emfietzoglou, Dimitris, Incerti, Sebastien, "A Geant4-DNA Evaluation of Radiation-Induced DNA Damage on a Human Fibroblast" in Cancers, 13, no. 19 (2021):4940, https://doi.org/10.3390/cancers13194940 . .