Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels
Само за регистроване кориснике
2021
Аутори
Zmejkoski, DanicaZdravković, Nemanja M.
Trišić, Dijana D.
Budimir, Milica
Marković, Zoran M.
Kozyrovska, Natalia O.
Todorović-Marković, Biljana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents. New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) – BC-Chi and chitosan nanoparticles (nChiD) – BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro ...healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents.
Кључне речи:
Anti-biofilm activity / Bacterial cellulose / Chitosan polymer and nanoparticles / Chronic wound treatment / DressingsИзвор:
International Journal of Biological Macromolecules, 2021, 191, 315-323Финансирање / пројекти:
- Увођење и евалуација нове молекуларне методе за брзо откривање mecA гена стафилокока директно у брисевима узетим од људи, животиња и из њиховог окружења (RS-MESTD-Technological Development (TD or TR)-31079)
- National Academy of Sciences of Ukraine [grant 47/2015-2016]
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-2/2021-14/20-032102]
DOI: 10.1016/j.ijbiomac.2021.09.118
ISSN: 0141-8130
PubMed: 34562533
WoS: 000710246700008
Scopus: 2-s2.0-85115811700
Колекције
Институција/група
VinčaTY - JOUR AU - Zmejkoski, Danica AU - Zdravković, Nemanja M. AU - Trišić, Dijana D. AU - Budimir, Milica AU - Marković, Zoran M. AU - Kozyrovska, Natalia O. AU - Todorović-Marković, Biljana PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9957 AB - Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents. New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) – BC-Chi and chitosan nanoparticles (nChiD) – BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents. T2 - International Journal of Biological Macromolecules T1 - Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels VL - 191 SP - 315 EP - 323 DO - 10.1016/j.ijbiomac.2021.09.118 ER -
@article{ author = "Zmejkoski, Danica and Zdravković, Nemanja M. and Trišić, Dijana D. and Budimir, Milica and Marković, Zoran M. and Kozyrovska, Natalia O. and Todorović-Marković, Biljana", year = "2021", abstract = "Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents. New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) – BC-Chi and chitosan nanoparticles (nChiD) – BC-nChiD. nChiD were obtained by gamma irradiation at doses: 20, 40 and 60 kGy. Physical and chemical analyses showed incorporation of Chi and encapsulation of nChiD into BC. The BC-Chi has the highest average surface roughness. BC-nChiD hydrogels show an irradiated dose-dependent increase of average surface roughness. New composite hydrogels are biocompatible with excellent anti-biofilm potential with up to 90% reduction of viable biofilm and up to 65% reduction of biofilm height. The BC-nChiD showed better dressing characteristics: higher porosity, higher wound fluid absorption and faster migration of cells (in vitro healing). All obtained results confirmed both composite hydrogels as promising chronic wound healing agents.", journal = "International Journal of Biological Macromolecules", title = "Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels", volume = "191", pages = "315-323", doi = "10.1016/j.ijbiomac.2021.09.118" }
Zmejkoski, D., Zdravković, N. M., Trišić, D. D., Budimir, M., Marković, Z. M., Kozyrovska, N. O.,& Todorović-Marković, B.. (2021). Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels. in International Journal of Biological Macromolecules, 191, 315-323. https://doi.org/10.1016/j.ijbiomac.2021.09.118
Zmejkoski D, Zdravković NM, Trišić DD, Budimir M, Marković ZM, Kozyrovska NO, Todorović-Marković B. Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels. in International Journal of Biological Macromolecules. 2021;191:315-323. doi:10.1016/j.ijbiomac.2021.09.118 .
Zmejkoski, Danica, Zdravković, Nemanja M., Trišić, Dijana D., Budimir, Milica, Marković, Zoran M., Kozyrovska, Natalia O., Todorović-Marković, Biljana, "Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels" in International Journal of Biological Macromolecules, 191 (2021):315-323, https://doi.org/10.1016/j.ijbiomac.2021.09.118 . .