Sensitivity of HTB140 cell exposed to protons and alkylating agents
2006
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Аутори
Korićanac, LelaPetrović, Ivan M.
Privitera, Giuseppe
Cuttone, Giacomo
Ristić-Fira, Aleksandra
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
Malignant melanoma is a highly aggressive cancer with a poor prognosis due to resistance to radiotherapy and chemotherapy regimens. The mainstay of treatment remains DNA-alkylatingagent dacarbazine (DTIC). Fotemustine (FM), chloroethylnitrosourea agent, also has demonstrated significant antitumoral effects in malignantmelanoma. However, the resistance of melanoma cells limits their clinical application. In order to enhance the inhibition of melanoma cell growth, in this study, combined treatment of FM and DTIC with proton irradiation, was investigated. We analyzed the effects of combined treatment on HTB140 melanoma cell viability and proliferation. Significant inhibition of cell growth, especially cell proliferation, was obtained after treatment with protons and FM compare to single irradiation or drug treatment. Treatment with protons and DTIC has shown improved growth inhibition compare to appropriate single drug treatment, but not compare to irradiation as a single treatment.
Извор:
Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry, 2006, 451-453Издавач:
- Society of Physical Chemists of Serbia
Напомена:
- Physical chemistry 2006 : 8th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-29 September 2006
Колекције
Институција/група
VinčaTY - CONF AU - Korićanac, Lela AU - Petrović, Ivan M. AU - Privitera, Giuseppe AU - Cuttone, Giacomo AU - Ristić-Fira, Aleksandra PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9441 AB - Malignant melanoma is a highly aggressive cancer with a poor prognosis due to resistance to radiotherapy and chemotherapy regimens. The mainstay of treatment remains DNA-alkylatingagent dacarbazine (DTIC). Fotemustine (FM), chloroethylnitrosourea agent, also has demonstrated significant antitumoral effects in malignantmelanoma. However, the resistance of melanoma cells limits their clinical application. In order to enhance the inhibition of melanoma cell growth, in this study, combined treatment of FM and DTIC with proton irradiation, was investigated. We analyzed the effects of combined treatment on HTB140 melanoma cell viability and proliferation. Significant inhibition of cell growth, especially cell proliferation, was obtained after treatment with protons and FM compare to single irradiation or drug treatment. Treatment with protons and DTIC has shown improved growth inhibition compare to appropriate single drug treatment, but not compare to irradiation as a single treatment. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry T1 - Sensitivity of HTB140 cell exposed to protons and alkylating agents SP - 451 EP - 453 UR - https://hdl.handle.net/21.15107/rcub_vinar_9441 ER -
@conference{ author = "Korićanac, Lela and Petrović, Ivan M. and Privitera, Giuseppe and Cuttone, Giacomo and Ristić-Fira, Aleksandra", year = "2006", abstract = "Malignant melanoma is a highly aggressive cancer with a poor prognosis due to resistance to radiotherapy and chemotherapy regimens. The mainstay of treatment remains DNA-alkylatingagent dacarbazine (DTIC). Fotemustine (FM), chloroethylnitrosourea agent, also has demonstrated significant antitumoral effects in malignantmelanoma. However, the resistance of melanoma cells limits their clinical application. In order to enhance the inhibition of melanoma cell growth, in this study, combined treatment of FM and DTIC with proton irradiation, was investigated. We analyzed the effects of combined treatment on HTB140 melanoma cell viability and proliferation. Significant inhibition of cell growth, especially cell proliferation, was obtained after treatment with protons and FM compare to single irradiation or drug treatment. Treatment with protons and DTIC has shown improved growth inhibition compare to appropriate single drug treatment, but not compare to irradiation as a single treatment.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry", title = "Sensitivity of HTB140 cell exposed to protons and alkylating agents", pages = "451-453", url = "https://hdl.handle.net/21.15107/rcub_vinar_9441" }
Korićanac, L., Petrović, I. M., Privitera, G., Cuttone, G.,& Ristić-Fira, A.. (2006). Sensitivity of HTB140 cell exposed to protons and alkylating agents. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry Society of Physical Chemists of Serbia., 451-453. https://hdl.handle.net/21.15107/rcub_vinar_9441
Korićanac L, Petrović IM, Privitera G, Cuttone G, Ristić-Fira A. Sensitivity of HTB140 cell exposed to protons and alkylating agents. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:451-453. https://hdl.handle.net/21.15107/rcub_vinar_9441 .
Korićanac, Lela, Petrović, Ivan M., Privitera, Giuseppe, Cuttone, Giacomo, Ristić-Fira, Aleksandra, "Sensitivity of HTB140 cell exposed to protons and alkylating agents" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):451-453, https://hdl.handle.net/21.15107/rcub_vinar_9441 .