Inhibition of ache by malathion and some structuraly similar compounds
Аутори
Krstić, Danijela Z.Bavcon Kralj, Mojca
Trebše, Polonca
Čolović, Mirjana B.
Krinulović, Katarina
Vasić, Vesna M.
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
Inhibition of bovine serum acetylcholinesterase by in vitro exposure to malathion, malaoxon, isomalathion and diethyl maleate was investigated to elucidate the mechanism of the enzyme interaction with structurally similar organophosphorus compounds. IC50 (half maximum inhibitory concentrations) were determined by Hill analysis of experimentally obtained inhibition curves. The values (2.87 ± 0.24)x10-6 M, (2.65±0.61)x10-6M, (3.01±0.36)x10-4 M and (5.69 ±0.7)x10-2 M were obtained for malaoxon, isomalathion, malathion and their hydrolysis product diethyl maleate, respectively. The relationship between the structure of the compounds and their potency to inhibit the enzyme activity was discussed.
Извор:
Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry, 2006, 401-413Издавач:
- Society of Physical Chemists of Serbia
Напомена:
- Physical chemistry 2006 : 8th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-29 September 2006
Колекције
Институција/група
VinčaTY - CONF AU - Krstić, Danijela Z. AU - Bavcon Kralj, Mojca AU - Trebše, Polonca AU - Čolović, Mirjana B. AU - Krinulović, Katarina AU - Vasić, Vesna M. PY - 2006 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9429 AB - Inhibition of bovine serum acetylcholinesterase by in vitro exposure to malathion, malaoxon, isomalathion and diethyl maleate was investigated to elucidate the mechanism of the enzyme interaction with structurally similar organophosphorus compounds. IC50 (half maximum inhibitory concentrations) were determined by Hill analysis of experimentally obtained inhibition curves. The values (2.87 ± 0.24)x10-6 M, (2.65±0.61)x10-6M, (3.01±0.36)x10-4 M and (5.69 ±0.7)x10-2 M were obtained for malaoxon, isomalathion, malathion and their hydrolysis product diethyl maleate, respectively. The relationship between the structure of the compounds and their potency to inhibit the enzyme activity was discussed. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry T1 - Inhibition of ache by malathion and some structuraly similar compounds SP - 401 EP - 413 UR - https://hdl.handle.net/21.15107/rcub_vinar_9429 ER -
@conference{ author = "Krstić, Danijela Z. and Bavcon Kralj, Mojca and Trebše, Polonca and Čolović, Mirjana B. and Krinulović, Katarina and Vasić, Vesna M.", year = "2006", abstract = "Inhibition of bovine serum acetylcholinesterase by in vitro exposure to malathion, malaoxon, isomalathion and diethyl maleate was investigated to elucidate the mechanism of the enzyme interaction with structurally similar organophosphorus compounds. IC50 (half maximum inhibitory concentrations) were determined by Hill analysis of experimentally obtained inhibition curves. The values (2.87 ± 0.24)x10-6 M, (2.65±0.61)x10-6M, (3.01±0.36)x10-4 M and (5.69 ±0.7)x10-2 M were obtained for malaoxon, isomalathion, malathion and their hydrolysis product diethyl maleate, respectively. The relationship between the structure of the compounds and their potency to inhibit the enzyme activity was discussed.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry", title = "Inhibition of ache by malathion and some structuraly similar compounds", pages = "401-413", url = "https://hdl.handle.net/21.15107/rcub_vinar_9429" }
Krstić, D. Z., Bavcon Kralj, M., Trebše, P., Čolović, M. B., Krinulović, K.,& Vasić, V. M.. (2006). Inhibition of ache by malathion and some structuraly similar compounds. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry Society of Physical Chemists of Serbia., 401-413. https://hdl.handle.net/21.15107/rcub_vinar_9429
Krstić DZ, Bavcon Kralj M, Trebše P, Čolović MB, Krinulović K, Vasić VM. Inhibition of ache by malathion and some structuraly similar compounds. in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry. 2006;:401-413. https://hdl.handle.net/21.15107/rcub_vinar_9429 .
Krstić, Danijela Z., Bavcon Kralj, Mojca, Trebše, Polonca, Čolović, Mirjana B., Krinulović, Katarina, Vasić, Vesna M., "Inhibition of ache by malathion and some structuraly similar compounds" in Physical chemistry 2006: 8th international conference on fundemental and applied aspract of physical chemistry (2006):401-413, https://hdl.handle.net/21.15107/rcub_vinar_9429 .