Physicochemical evaluation of Technetium-99m complexes with baclofen
Аутори
Stanković, Dalibor M.Janković, Drina
Mirković, Marija D.
Lakić, Mladen
Vranješ-Đurić, Sanja
Nikolić, Nadežda S.
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
The 99mTc-labeling of baclofen (Bac), a muscle relaxant, as well as
physicochemical properties of the labeled compounds are investigated. Two
different approaches for the labeling with 99mTc have been studied: direct reduction
with tin(II)chloride and the 'organometallic approach' using [99mTc(CO)3(H2O)3]
+
precursor. The direct labeling approach was not successful and the yield was poor.
The use of [99mTc(CO)3(H2O)3]+ precursor pointed at the formation of 99mTc(I)
coordinated complexes with high yield. In this approach, pH didn’t influence the
yields. Promising results of in vitro experiments suggest that 99mTc(I)-baclofen may
be of potential use for diagnosis of some central nervous system disorders.
Извор:
Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2012, 2, 591-593Издавач:
- Society of Physical Chemists of Serbia
Напомена:
- Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 24-28 September 2012
Колекције
Институција/група
VinčaTY - CONF AU - Stanković, Dalibor M. AU - Janković, Drina AU - Mirković, Marija D. AU - Lakić, Mladen AU - Vranješ-Đurić, Sanja AU - Nikolić, Nadežda S. PY - 2012 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9353 AB - The 99mTc-labeling of baclofen (Bac), a muscle relaxant, as well as physicochemical properties of the labeled compounds are investigated. Two different approaches for the labeling with 99mTc have been studied: direct reduction with tin(II)chloride and the 'organometallic approach' using [99mTc(CO)3(H2O)3] + precursor. The direct labeling approach was not successful and the yield was poor. The use of [99mTc(CO)3(H2O)3]+ precursor pointed at the formation of 99mTc(I) coordinated complexes with high yield. In this approach, pH didn’t influence the yields. Promising results of in vitro experiments suggest that 99mTc(I)-baclofen may be of potential use for diagnosis of some central nervous system disorders. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry T1 - Physicochemical evaluation of Technetium-99m complexes with baclofen VL - 2 SP - 591 EP - 593 UR - https://hdl.handle.net/21.15107/rcub_vinar_9353 ER -
@conference{ author = "Stanković, Dalibor M. and Janković, Drina and Mirković, Marija D. and Lakić, Mladen and Vranješ-Đurić, Sanja and Nikolić, Nadežda S.", year = "2012", abstract = "The 99mTc-labeling of baclofen (Bac), a muscle relaxant, as well as physicochemical properties of the labeled compounds are investigated. Two different approaches for the labeling with 99mTc have been studied: direct reduction with tin(II)chloride and the 'organometallic approach' using [99mTc(CO)3(H2O)3] + precursor. The direct labeling approach was not successful and the yield was poor. The use of [99mTc(CO)3(H2O)3]+ precursor pointed at the formation of 99mTc(I) coordinated complexes with high yield. In this approach, pH didn’t influence the yields. Promising results of in vitro experiments suggest that 99mTc(I)-baclofen may be of potential use for diagnosis of some central nervous system disorders.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry", title = "Physicochemical evaluation of Technetium-99m complexes with baclofen", volume = "2", pages = "591-593", url = "https://hdl.handle.net/21.15107/rcub_vinar_9353" }
Stanković, D. M., Janković, D., Mirković, M. D., Lakić, M., Vranješ-Đurić, S.,& Nikolić, N. S.. (2012). Physicochemical evaluation of Technetium-99m complexes with baclofen. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia., 2, 591-593. https://hdl.handle.net/21.15107/rcub_vinar_9353
Stanković DM, Janković D, Mirković MD, Lakić M, Vranješ-Đurić S, Nikolić NS. Physicochemical evaluation of Technetium-99m complexes with baclofen. in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry. 2012;2:591-593. https://hdl.handle.net/21.15107/rcub_vinar_9353 .
Stanković, Dalibor M., Janković, Drina, Mirković, Marija D., Lakić, Mladen, Vranješ-Đurić, Sanja, Nikolić, Nadežda S., "Physicochemical evaluation of Technetium-99m complexes with baclofen" in Physical chemistry 2012 : 11th international conference on fundamental and applied aspects of physical chemistry, 2 (2012):591-593, https://hdl.handle.net/21.15107/rcub_vinar_9353 .