Compromised glutathione-dependent redox system of chronically-isolated rats: a harmful side effect of clozapine
Конференцијски прилог (Објављена верзија)
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Society of Physical Chemists of Serbia
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Changes in glutathione (GSH)-related systems are implicated in depressive
disorders. Since chronic psychosocial stress contributes to depression, we
investigated the effects of 21d of chronic social isolation (CSIS) stress, an
animal model of depression, as well as chronic administration of clozapine,
an atypical antipsychotic, on GSH content, glutathione peroxidase (GPx)
and glutathione reductase (GLR) in the prefrontal cortex of rats. Increased
GPx protein expression and its activity in clozapine-treated (controls or
chronically-isolated) rats as well as in CSIS group were found. Nonetheless,
clozapine administration caused decrease in GSH content but no effects on
GLR in controls and CSIS group. Data indicate that CSIS compromises
GSH-dependent redox system promoting oxidative stress in rat prefrontal
cortex which can’t be protected by clozapine. Moreover, clozapine
administration in controls has a harmful side effect on this redox system.
Извор:
Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, 2014, 1113-1116Издавач:
- Society of Physical Chemists of Serbia
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Институција/група
VinčaTY - CONF AU - Bošković, Maja AU - Todorović, Nevena AU - Filipović, Dragana PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9266 AB - Changes in glutathione (GSH)-related systems are implicated in depressive disorders. Since chronic psychosocial stress contributes to depression, we investigated the effects of 21d of chronic social isolation (CSIS) stress, an animal model of depression, as well as chronic administration of clozapine, an atypical antipsychotic, on GSH content, glutathione peroxidase (GPx) and glutathione reductase (GLR) in the prefrontal cortex of rats. Increased GPx protein expression and its activity in clozapine-treated (controls or chronically-isolated) rats as well as in CSIS group were found. Nonetheless, clozapine administration caused decrease in GSH content but no effects on GLR in controls and CSIS group. Data indicate that CSIS compromises GSH-dependent redox system promoting oxidative stress in rat prefrontal cortex which can’t be protected by clozapine. Moreover, clozapine administration in controls has a harmful side effect on this redox system. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry T1 - Compromised glutathione-dependent redox system of chronically-isolated rats: a harmful side effect of clozapine SP - 1113 EP - 1116 UR - https://hdl.handle.net/21.15107/rcub_vinar_9266 ER -
@conference{ author = "Bošković, Maja and Todorović, Nevena and Filipović, Dragana", year = "2014", abstract = "Changes in glutathione (GSH)-related systems are implicated in depressive disorders. Since chronic psychosocial stress contributes to depression, we investigated the effects of 21d of chronic social isolation (CSIS) stress, an animal model of depression, as well as chronic administration of clozapine, an atypical antipsychotic, on GSH content, glutathione peroxidase (GPx) and glutathione reductase (GLR) in the prefrontal cortex of rats. Increased GPx protein expression and its activity in clozapine-treated (controls or chronically-isolated) rats as well as in CSIS group were found. Nonetheless, clozapine administration caused decrease in GSH content but no effects on GLR in controls and CSIS group. Data indicate that CSIS compromises GSH-dependent redox system promoting oxidative stress in rat prefrontal cortex which can’t be protected by clozapine. Moreover, clozapine administration in controls has a harmful side effect on this redox system.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry", title = "Compromised glutathione-dependent redox system of chronically-isolated rats: a harmful side effect of clozapine", pages = "1113-1116", url = "https://hdl.handle.net/21.15107/rcub_vinar_9266" }
Bošković, M., Todorović, N.,& Filipović, D.. (2014). Compromised glutathione-dependent redox system of chronically-isolated rats: a harmful side effect of clozapine. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry Society of Physical Chemists of Serbia., 1113-1116. https://hdl.handle.net/21.15107/rcub_vinar_9266
Bošković M, Todorović N, Filipović D. Compromised glutathione-dependent redox system of chronically-isolated rats: a harmful side effect of clozapine. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;:1113-1116. https://hdl.handle.net/21.15107/rcub_vinar_9266 .
Bošković, Maja, Todorović, Nevena, Filipović, Dragana, "Compromised glutathione-dependent redox system of chronically-isolated rats: a harmful side effect of clozapine" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry (2014):1113-1116, https://hdl.handle.net/21.15107/rcub_vinar_9266 .