The potential of in vivo EPR in evaluating free radical reactions in irradiated rats and mechanisms of radioprotection
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
We investigated the potential of in vivoelectron paramagnetic resonance (EPR) in assessingchemical reactions that occur during ionizing irradiation and capabilities of two radioprotectors (an antibiotic, anisomycin and a naturally occurring tiol, Gl2011) to enhance survival during irradiation. Radioprotectors selected are supposed to have different modes of action and in vivoEPR was used to assess whether free radical scavenging has arole in their action as radioprotectors. Both compounds exhibited similar and highly efficient radioprotective capabilities according to the 30-days survival test (96% and 87%, respectively after the dose of 6.7 Gy). In vivoEPR showed that free radical scavenging has an important role in the action of GL2011, but not in the case of anisomycin. In conclusion, EPR have unique capabilities in studying free radicals in vivoand can beuseful addition to battery of methods neede...d to study radioprotectorsin vivo.
Извор:
Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry, 2016, 491-494Издавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Биомаркери у неуродегенеративним и малигним процесима (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41005)
Напомена:
- Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-30 September 2016.
Колекције
Институција/група
VinčaTY - CONF AU - Jovanović, M. AU - Šećerov, Bojana AU - Bačić, Goran PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9212 AB - We investigated the potential of in vivoelectron paramagnetic resonance (EPR) in assessingchemical reactions that occur during ionizing irradiation and capabilities of two radioprotectors (an antibiotic, anisomycin and a naturally occurring tiol, Gl2011) to enhance survival during irradiation. Radioprotectors selected are supposed to have different modes of action and in vivoEPR was used to assess whether free radical scavenging has arole in their action as radioprotectors. Both compounds exhibited similar and highly efficient radioprotective capabilities according to the 30-days survival test (96% and 87%, respectively after the dose of 6.7 Gy). In vivoEPR showed that free radical scavenging has an important role in the action of GL2011, but not in the case of anisomycin. In conclusion, EPR have unique capabilities in studying free radicals in vivoand can beuseful addition to battery of methods needed to study radioprotectorsin vivo. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry T1 - The potential of in vivo EPR in evaluating free radical reactions in irradiated rats and mechanisms of radioprotection SP - 491 EP - 494 UR - https://hdl.handle.net/21.15107/rcub_vinar_9212 ER -
@conference{ author = "Jovanović, M. and Šećerov, Bojana and Bačić, Goran", year = "2016", abstract = "We investigated the potential of in vivoelectron paramagnetic resonance (EPR) in assessingchemical reactions that occur during ionizing irradiation and capabilities of two radioprotectors (an antibiotic, anisomycin and a naturally occurring tiol, Gl2011) to enhance survival during irradiation. Radioprotectors selected are supposed to have different modes of action and in vivoEPR was used to assess whether free radical scavenging has arole in their action as radioprotectors. Both compounds exhibited similar and highly efficient radioprotective capabilities according to the 30-days survival test (96% and 87%, respectively after the dose of 6.7 Gy). In vivoEPR showed that free radical scavenging has an important role in the action of GL2011, but not in the case of anisomycin. In conclusion, EPR have unique capabilities in studying free radicals in vivoand can beuseful addition to battery of methods needed to study radioprotectorsin vivo.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry", title = "The potential of in vivo EPR in evaluating free radical reactions in irradiated rats and mechanisms of radioprotection", pages = "491-494", url = "https://hdl.handle.net/21.15107/rcub_vinar_9212" }
Jovanović, M., Šećerov, B.,& Bačić, G.. (2016). The potential of in vivo EPR in evaluating free radical reactions in irradiated rats and mechanisms of radioprotection. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry Society of Physical Chemists of Serbia., 491-494. https://hdl.handle.net/21.15107/rcub_vinar_9212
Jovanović M, Šećerov B, Bačić G. The potential of in vivo EPR in evaluating free radical reactions in irradiated rats and mechanisms of radioprotection. in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry. 2016;:491-494. https://hdl.handle.net/21.15107/rcub_vinar_9212 .
Jovanović, M., Šećerov, Bojana, Bačić, Goran, "The potential of in vivo EPR in evaluating free radical reactions in irradiated rats and mechanisms of radioprotection" in Physical chemistry 2016 : 13th international conference on fundamental and applied aspects of physical chemistry (2016):491-494, https://hdl.handle.net/21.15107/rcub_vinar_9212 .