Association of female gonadal hormones and immunity in depression
Конференцијски прилог (Објављена верзија)
,
Society of Physical Chemists of Serbia
Метаподаци
Приказ свих података о документуАпстракт
In this study, we examined the influence of immunity on depressive-like
behavior in females in the context of gonadal hormones. We used
neuroinflammatory model of depression elicited by lipopolysaccharide
(LPS) administration on naïve and ovariectomozed (OVX) females and
examined the effects of estradiol (E2) and/or progesterone (P4) replacement
therapy on Wistar rat behavior. LPS induced depressive–like behavior in
both naïve and OVX females. Our behavioral data indicated that E2 and P4
applied alone had opposite effects compared to the E2/P4 combination. The
supplementation of both hormones attenuates detrimental effects of LPSinduced
inflammation, particularly through stimulation of noradrenergic
transmission. Overall immune challenge with LPS is able to induce
depressive-like behavior either of naïve or ovariectomized females,
particularly depending on ovarian hormones background.
Извор:
Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, 2014, F-10-PИздавач:
- Society of Physical Chemists of Serbia
Финансирање / пројекти:
- Дефинисање кластера молекулских биомаркера за побољшану дијагностику и терапију поремећаја расположења (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41029)
Колекције
Институција/група
VinčaTY - CONF AU - Mitić, Miloš AU - Lukić, Iva AU - Đorđević, Jelena D. AU - Adžić, Miroslav PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9190 AB - In this study, we examined the influence of immunity on depressive-like behavior in females in the context of gonadal hormones. We used neuroinflammatory model of depression elicited by lipopolysaccharide (LPS) administration on naïve and ovariectomozed (OVX) females and examined the effects of estradiol (E2) and/or progesterone (P4) replacement therapy on Wistar rat behavior. LPS induced depressive–like behavior in both naïve and OVX females. Our behavioral data indicated that E2 and P4 applied alone had opposite effects compared to the E2/P4 combination. The supplementation of both hormones attenuates detrimental effects of LPSinduced inflammation, particularly through stimulation of noradrenergic transmission. Overall immune challenge with LPS is able to induce depressive-like behavior either of naïve or ovariectomized females, particularly depending on ovarian hormones background. PB - Society of Physical Chemists of Serbia C3 - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry T1 - Association of female gonadal hormones and immunity in depression VL - F-10-P UR - https://hdl.handle.net/21.15107/rcub_vinar_9190 ER -
@conference{ author = "Mitić, Miloš and Lukić, Iva and Đorđević, Jelena D. and Adžić, Miroslav", year = "2014", abstract = "In this study, we examined the influence of immunity on depressive-like behavior in females in the context of gonadal hormones. We used neuroinflammatory model of depression elicited by lipopolysaccharide (LPS) administration on naïve and ovariectomozed (OVX) females and examined the effects of estradiol (E2) and/or progesterone (P4) replacement therapy on Wistar rat behavior. LPS induced depressive–like behavior in both naïve and OVX females. Our behavioral data indicated that E2 and P4 applied alone had opposite effects compared to the E2/P4 combination. The supplementation of both hormones attenuates detrimental effects of LPSinduced inflammation, particularly through stimulation of noradrenergic transmission. Overall immune challenge with LPS is able to induce depressive-like behavior either of naïve or ovariectomized females, particularly depending on ovarian hormones background.", publisher = "Society of Physical Chemists of Serbia", journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry", title = "Association of female gonadal hormones and immunity in depression", volume = "F-10-P", url = "https://hdl.handle.net/21.15107/rcub_vinar_9190" }
Mitić, M., Lukić, I., Đorđević, J. D.,& Adžić, M.. (2014). Association of female gonadal hormones and immunity in depression. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry Society of Physical Chemists of Serbia., F-10-P. https://hdl.handle.net/21.15107/rcub_vinar_9190
Mitić M, Lukić I, Đorđević JD, Adžić M. Association of female gonadal hormones and immunity in depression. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;F-10-P. https://hdl.handle.net/21.15107/rcub_vinar_9190 .
Mitić, Miloš, Lukić, Iva, Đorđević, Jelena D., Adžić, Miroslav, "Association of female gonadal hormones and immunity in depression" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, F-10-P (2014), https://hdl.handle.net/21.15107/rcub_vinar_9190 .