Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo
Само за регистроване кориснике
2021
Аутори
Liang, XinyueXie, Yonghui
Wu, Junxin
Wang, Jing
Petković, Marijana
Stepić, Milutin
Zhao, Jinzhuo
Ma, Jiong
Mi, Lan
Чланак у часопису (Објављена верзија)
,
© 2020 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт
Photodynamic therapy (PDT) is a promising cancer treatment that can be implemented using various agents. The conventional photosensitizer Al (III) phthalocyanine chloride tetrasulfonic acid (Pc) has limitations of selectivity in tumor targeting, low affinity to cancer cells, and low two-photon absorption. This study presents a novel photosensitizer FA-TiO2-Pc, which has the TiO2 nanoparticle conjugated with a tumor targeting agent of folic acid (FA), and Pc. FA-TiO2-Pc possessed high targeted photodynamic therapeutic activity and excellent biocompatibility. This promising photosensitizer showed high therapeutic drug efficiency in vitro at a low concentration dose and short incubation time under one-photon excitation (OPE). In vivo, when treated with a low dose of FA-TiO2-Pc and low light irradiation, the tumor growth was depressed in mice bearing HeLa xenograft tumors with minimal side effects. In addition, the two-photon absorption of FA-TiO2-Pc was also enhanced compared to Pc, provi...ng that FA-TiO2-Pc system has a great potential to be used for the therapy of the folate receptor positive cancer cells in both OPE-PDT and two-photon excitation (TPE)-PDT agents. © 2020 Elsevier B.V.
Кључне речи:
Photodynamic therapy / Phthalocyanine / Titanium dioxide / Targeted delivery / Two-photon excitationИзвор:
Journal of Photochemistry and Photobiology B: Biology, 2021, 215, 112122-Финансирање / пројекти:
- National Natural Science Foundation of China (NSFC) [11574056]
- National Natural Science Foundation of China (NSFC) [81673125]
- National Natural Science Foundation of China (NSFC) [11804350]
- National Natural Science Foundation of China (NSFC) [61575046]
- Serbian Ministry of Education, Science and Technological Development (China-Serbia bilateral projects) [SINO-SERBIA2018002]
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-200017)
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-00-478/2018-09/16]
- Fudan University-CIOMP Joint Fund [FC2017-007]
- Fudan University-CIOMP Joint Fund [FC2018-001]
- Pioneering Project of Academy for Engineering and Technology, Fudan University [gyy2018-001]
- Pioneering Project of Academy for Engineering and Technology, Fudan University [gyy2018-002]
- CURE [16927]
- Natural Science Foundation of Shanghai [20ZR1405100]
- Science and Technology Research Program of Shanghai [19DZ2282100]
- Shanghai key discipline construction plan (2020-2022) [GWV-10.1-XK01]
Напомена:
- Fig. 1B and C was modified from Servier Medical Art (http://smart.servier.com/), licensed under a Creative Common Attribution 3.0 Generic License. (https://creativecommons.org/licenses/by/3.0/).
DOI: 10.1016/j.jphotobiol.2020.112122
ISSN: 1011-1344
PubMed: 33433386
WoS: 000618601100003
Scopus: 2-s2.0-85098947439
Институција/група
VinčaTY - JOUR AU - Liang, Xinyue AU - Xie, Yonghui AU - Wu, Junxin AU - Wang, Jing AU - Petković, Marijana AU - Stepić, Milutin AU - Zhao, Jinzhuo AU - Ma, Jiong AU - Mi, Lan PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9176 AB - Photodynamic therapy (PDT) is a promising cancer treatment that can be implemented using various agents. The conventional photosensitizer Al (III) phthalocyanine chloride tetrasulfonic acid (Pc) has limitations of selectivity in tumor targeting, low affinity to cancer cells, and low two-photon absorption. This study presents a novel photosensitizer FA-TiO2-Pc, which has the TiO2 nanoparticle conjugated with a tumor targeting agent of folic acid (FA), and Pc. FA-TiO2-Pc possessed high targeted photodynamic therapeutic activity and excellent biocompatibility. This promising photosensitizer showed high therapeutic drug efficiency in vitro at a low concentration dose and short incubation time under one-photon excitation (OPE). In vivo, when treated with a low dose of FA-TiO2-Pc and low light irradiation, the tumor growth was depressed in mice bearing HeLa xenograft tumors with minimal side effects. In addition, the two-photon absorption of FA-TiO2-Pc was also enhanced compared to Pc, proving that FA-TiO2-Pc system has a great potential to be used for the therapy of the folate receptor positive cancer cells in both OPE-PDT and two-photon excitation (TPE)-PDT agents. © 2020 Elsevier B.V. T2 - Journal of Photochemistry and Photobiology B: Biology T1 - Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo VL - 215 SP - 112122 DO - 10.1016/j.jphotobiol.2020.112122 ER -
@article{ author = "Liang, Xinyue and Xie, Yonghui and Wu, Junxin and Wang, Jing and Petković, Marijana and Stepić, Milutin and Zhao, Jinzhuo and Ma, Jiong and Mi, Lan", year = "2021", abstract = "Photodynamic therapy (PDT) is a promising cancer treatment that can be implemented using various agents. The conventional photosensitizer Al (III) phthalocyanine chloride tetrasulfonic acid (Pc) has limitations of selectivity in tumor targeting, low affinity to cancer cells, and low two-photon absorption. This study presents a novel photosensitizer FA-TiO2-Pc, which has the TiO2 nanoparticle conjugated with a tumor targeting agent of folic acid (FA), and Pc. FA-TiO2-Pc possessed high targeted photodynamic therapeutic activity and excellent biocompatibility. This promising photosensitizer showed high therapeutic drug efficiency in vitro at a low concentration dose and short incubation time under one-photon excitation (OPE). In vivo, when treated with a low dose of FA-TiO2-Pc and low light irradiation, the tumor growth was depressed in mice bearing HeLa xenograft tumors with minimal side effects. In addition, the two-photon absorption of FA-TiO2-Pc was also enhanced compared to Pc, proving that FA-TiO2-Pc system has a great potential to be used for the therapy of the folate receptor positive cancer cells in both OPE-PDT and two-photon excitation (TPE)-PDT agents. © 2020 Elsevier B.V.", journal = "Journal of Photochemistry and Photobiology B: Biology", title = "Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo", volume = "215", pages = "112122", doi = "10.1016/j.jphotobiol.2020.112122" }
Liang, X., Xie, Y., Wu, J., Wang, J., Petković, M., Stepić, M., Zhao, J., Ma, J.,& Mi, L.. (2021). Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo. in Journal of Photochemistry and Photobiology B: Biology, 215, 112122. https://doi.org/10.1016/j.jphotobiol.2020.112122
Liang X, Xie Y, Wu J, Wang J, Petković M, Stepić M, Zhao J, Ma J, Mi L. Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo. in Journal of Photochemistry and Photobiology B: Biology. 2021;215:112122. doi:10.1016/j.jphotobiol.2020.112122 .
Liang, Xinyue, Xie, Yonghui, Wu, Junxin, Wang, Jing, Petković, Marijana, Stepić, Milutin, Zhao, Jinzhuo, Ma, Jiong, Mi, Lan, "Functional titanium dioxide nanoparticle conjugated with phthalocyanine and folic acid as a promising photosensitizer for targeted photodynamic therapy in vitro and in vivo" in Journal of Photochemistry and Photobiology B: Biology, 215 (2021):112122, https://doi.org/10.1016/j.jphotobiol.2020.112122 . .