Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation
Само за регистроване кориснике
2020
Аутори
Stanisavljević, AndrijanaPerić, Ivana
Gass, Peter
Inta, Dragos
Lang, Undine E.
Borgwardt, Stefan
Filipović, Dragana
Чланак у часопису (Објављена верзија)
,
© 2020 Elsevier Inc
Метаподаци
Приказ свих података о документуАпстракт
Antidepressant fluoxetine (Flx) is the first therapeutic choice for the treatment of major depression (MD), however neuroanatomical spots of its action remain unclear. Immunohistochemical detection of c-Fos protein expression has been used for mapping activated neuronal circuits upon various stressors and drugs. We investigated the effect of 3 weeks of Flx treatment (15 mg/kg/day) on changes in neuronal activity, by mapping the number of c-Fos+ cells, in several brain subregions in adult male rats of control and following 3 weeks of chronic social isolation (CSIS), an animal model of depression. The aim was to identify brain subregions activated by vehicle or Flx treatment in both controls or simultaneously applied with CSIS. Flx prevented depressive- and anxiety-like behaviors in CSIS rats. In controls, Flx increased the number of c-Fos+ cells in the anterior/posterior piriform cortex (aPirCx, pPirCx), retrosplenial cortex dysgranular (RSD) and granular, c region (RSGc), dorsal hippoc...ampal subregions (CA1d, CA2, CA3d, DGd), lateral habenula (LHB), paraventricular thalamic nucleus, posterior part (PVP) and lateral/basolateral complex of amygdala (LA/BL). CSIS-induced neuronal activation was observed in brain subregions implicated in mood and other mental disorders such as aPirCx, pPirCx, caudate putamen (CPu), acumbens nucleus shell (AcbSh), RSD, RSGc, DGd, PVP and LA/BL. Flx increased neuronal activation in both controls and CSIS rats in the CA1d, CA2, CA3d, PVP, LA/BL, while in striatum increased neuronal activation was observed only in CSIS. Our data identify activated CSIS-related brain subregions and/or Flx treatment, in which Flx increased c-Fos protein expression in CSIS rats.
Кључне речи:
Fluoxetine / Chronic social isolation / c-Fos / Brain subregionИзвор:
Brain Research Bulletin, 2020, 163, 95-108Финансирање / пројекти:
- Ministry of Education, Science and Technological Development of the Republic of Serbia
- German Research Foundation (DFG) [DI 168/3-1]
- Ingeborg Stander Foundation
- Federal Ministry of Education & Research (BMBF) [01EW1807A]
- Swiss National Science Foundation (SNSF) [186346]
DOI: 10.1016/j.brainresbull.2020.07.021
ISSN: 0361-9230
PubMed: 32730865
WoS: 000566474100011
Scopus: 2-s2.0-85089014943
Институција/група
VinčaTY - JOUR AU - Stanisavljević, Andrijana AU - Perić, Ivana AU - Gass, Peter AU - Inta, Dragos AU - Lang, Undine E. AU - Borgwardt, Stefan AU - Filipović, Dragana PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9116 AB - Antidepressant fluoxetine (Flx) is the first therapeutic choice for the treatment of major depression (MD), however neuroanatomical spots of its action remain unclear. Immunohistochemical detection of c-Fos protein expression has been used for mapping activated neuronal circuits upon various stressors and drugs. We investigated the effect of 3 weeks of Flx treatment (15 mg/kg/day) on changes in neuronal activity, by mapping the number of c-Fos+ cells, in several brain subregions in adult male rats of control and following 3 weeks of chronic social isolation (CSIS), an animal model of depression. The aim was to identify brain subregions activated by vehicle or Flx treatment in both controls or simultaneously applied with CSIS. Flx prevented depressive- and anxiety-like behaviors in CSIS rats. In controls, Flx increased the number of c-Fos+ cells in the anterior/posterior piriform cortex (aPirCx, pPirCx), retrosplenial cortex dysgranular (RSD) and granular, c region (RSGc), dorsal hippocampal subregions (CA1d, CA2, CA3d, DGd), lateral habenula (LHB), paraventricular thalamic nucleus, posterior part (PVP) and lateral/basolateral complex of amygdala (LA/BL). CSIS-induced neuronal activation was observed in brain subregions implicated in mood and other mental disorders such as aPirCx, pPirCx, caudate putamen (CPu), acumbens nucleus shell (AcbSh), RSD, RSGc, DGd, PVP and LA/BL. Flx increased neuronal activation in both controls and CSIS rats in the CA1d, CA2, CA3d, PVP, LA/BL, while in striatum increased neuronal activation was observed only in CSIS. Our data identify activated CSIS-related brain subregions and/or Flx treatment, in which Flx increased c-Fos protein expression in CSIS rats. T2 - Brain Research Bulletin T1 - Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation VL - 163 SP - 95 EP - 108 DO - 10.1016/j.brainresbull.2020.07.021 ER -
@article{ author = "Stanisavljević, Andrijana and Perić, Ivana and Gass, Peter and Inta, Dragos and Lang, Undine E. and Borgwardt, Stefan and Filipović, Dragana", year = "2020", abstract = "Antidepressant fluoxetine (Flx) is the first therapeutic choice for the treatment of major depression (MD), however neuroanatomical spots of its action remain unclear. Immunohistochemical detection of c-Fos protein expression has been used for mapping activated neuronal circuits upon various stressors and drugs. We investigated the effect of 3 weeks of Flx treatment (15 mg/kg/day) on changes in neuronal activity, by mapping the number of c-Fos+ cells, in several brain subregions in adult male rats of control and following 3 weeks of chronic social isolation (CSIS), an animal model of depression. The aim was to identify brain subregions activated by vehicle or Flx treatment in both controls or simultaneously applied with CSIS. Flx prevented depressive- and anxiety-like behaviors in CSIS rats. In controls, Flx increased the number of c-Fos+ cells in the anterior/posterior piriform cortex (aPirCx, pPirCx), retrosplenial cortex dysgranular (RSD) and granular, c region (RSGc), dorsal hippocampal subregions (CA1d, CA2, CA3d, DGd), lateral habenula (LHB), paraventricular thalamic nucleus, posterior part (PVP) and lateral/basolateral complex of amygdala (LA/BL). CSIS-induced neuronal activation was observed in brain subregions implicated in mood and other mental disorders such as aPirCx, pPirCx, caudate putamen (CPu), acumbens nucleus shell (AcbSh), RSD, RSGc, DGd, PVP and LA/BL. Flx increased neuronal activation in both controls and CSIS rats in the CA1d, CA2, CA3d, PVP, LA/BL, while in striatum increased neuronal activation was observed only in CSIS. Our data identify activated CSIS-related brain subregions and/or Flx treatment, in which Flx increased c-Fos protein expression in CSIS rats.", journal = "Brain Research Bulletin", title = "Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation", volume = "163", pages = "95-108", doi = "10.1016/j.brainresbull.2020.07.021" }
Stanisavljević, A., Perić, I., Gass, P., Inta, D., Lang, U. E., Borgwardt, S.,& Filipović, D.. (2020). Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation. in Brain Research Bulletin, 163, 95-108. https://doi.org/10.1016/j.brainresbull.2020.07.021
Stanisavljević A, Perić I, Gass P, Inta D, Lang UE, Borgwardt S, Filipović D. Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation. in Brain Research Bulletin. 2020;163:95-108. doi:10.1016/j.brainresbull.2020.07.021 .
Stanisavljević, Andrijana, Perić, Ivana, Gass, Peter, Inta, Dragos, Lang, Undine E., Borgwardt, Stefan, Filipović, Dragana, "Fluoxetine modulates neuronal activity in stress-related limbic areas of adult rats subjected to the chronic social isolation" in Brain Research Bulletin, 163 (2020):95-108, https://doi.org/10.1016/j.brainresbull.2020.07.021 . .