Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics
Аутори
Todorović, LidijaMandušić, Vesna
Vučetić-Tadić, Biljana
Živaljević, Vladan
Paunović, Ivan
Stanojević, Boban
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its... prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.
Кључне речи:
miR-30a-3p / papillary thyroid cancer (PTC) / thyroid cancer / expression / advanced stageИзвор:
Archives of Biological Sciences, 2020, 72, 1, 31-36Финансирање / пројекти:
- Молекуларне детерминанте за дизајн тумор маркера (RS-MESTD-Basic Research (BR or ON)-173049)
DOI: 10.2298/ABS191004063T
ISSN: 0354-4664
WoS: 000524505000004
Scopus: 2-s2.0-85086789812
Институција/група
VinčaTY - JOUR AU - Todorović, Lidija AU - Mandušić, Vesna AU - Vučetić-Tadić, Biljana AU - Živaljević, Vladan AU - Paunović, Ivan AU - Stanojević, Boban PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9055 AB - A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations. T2 - Archives of Biological Sciences T1 - Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics VL - 72 IS - 1 SP - 31 EP - 36 DO - 10.2298/ABS191004063T ER -
@article{ author = "Todorović, Lidija and Mandušić, Vesna and Vučetić-Tadić, Biljana and Živaljević, Vladan and Paunović, Ivan and Stanojević, Boban", year = "2020", abstract = "A growing number of studies suggest a tumor suppressive role and potential prognostic significance of miR- 30a-3p in different types of cancer. However, relatively few studies have focused on this microRNA in neoplastic thyroid lesions, including papillary thyroid cancer (PTC). The aim of our study was to shed more light on the potential involvement and clinical relevance of miR-30a-3p in this type of cancer. We examined the expression levels of this microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using quantitative RT-PCR. We analyzed their association with clinical and histopathological parameters. The results revealed that miR-30a-3p was significantly downregulated in the majority of PTC tissues compared to corresponding non-tumor tissues. Moreover, decreased expression of miR-30a-3p was associated with advanced clinical stage, presence of multiple tumor foci and capsular invasion, suggesting a role in aggressive disease. Although the role of this microRNA and its prognostic utility remain to be elucidated, the presented data suggest that downregulated expression of miR-30a-3p indicates poorer prognosis in PTC patients, warranting further investigations.", journal = "Archives of Biological Sciences", title = "Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics", volume = "72", number = "1", pages = "31-36", doi = "10.2298/ABS191004063T" }
Todorović, L., Mandušić, V., Vučetić-Tadić, B., Živaljević, V., Paunović, I.,& Stanojević, B.. (2020). Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics. in Archives of Biological Sciences, 72(1), 31-36. https://doi.org/10.2298/ABS191004063T
Todorović L, Mandušić V, Vučetić-Tadić B, Živaljević V, Paunović I, Stanojević B. Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics. in Archives of Biological Sciences. 2020;72(1):31-36. doi:10.2298/ABS191004063T .
Todorović, Lidija, Mandušić, Vesna, Vučetić-Tadić, Biljana, Živaljević, Vladan, Paunović, Ivan, Stanojević, Boban, "Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics" in Archives of Biological Sciences, 72, no. 1 (2020):31-36, https://doi.org/10.2298/ABS191004063T . .