Drug delivery systems based on nanoparticles and related nanostructures
Само за регистроване кориснике
2020
Чланак у часопису (Објављена верзија)
,
© 2020 Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт
A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of t...he delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.
Кључне речи:
Biomedical application / Computational modeling / Drug carriers / Drug delivery / HSA / NanoparticlesИзвор:
European Journal of Pharmaceutical Sciences, 2020, 151, 105412-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
DOI: 10.1016/j.ejps.2020.105412
ISSN: 0928-0987
PubMed: 32505796
Scopus: 2-s2.0-85086767538
Институција/група
VinčaTY - JOUR AU - Vujačić Nikezić, Ana V. AU - Bondžić, Aleksandra M. AU - Vasić, Vesna M. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/9049 AB - A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment. T2 - European Journal of Pharmaceutical Sciences T1 - Drug delivery systems based on nanoparticles and related nanostructures VL - 151 SP - 105412 DO - 10.1016/j.ejps.2020.105412 ER -
@article{ author = "Vujačić Nikezić, Ana V. and Bondžić, Aleksandra M. and Vasić, Vesna M.", year = "2020", abstract = "A new approach to drug design based on nanoparticles and related nanostructures for effective drug delivery, is of great importance in future medical treatment, especially for cancer therapy. Nanomaterials hold tremendous potential for increasing the efficiency of drug delivery, with a high degree of biocompatibility. Additionally, for biomedical applications, they must be biodegradable, have prolonged circulation half-life, not tend to aggregate or cause an inflammatory response in the body and to be cost-effective. The efficacy of such structures is highly dependent on their chemical properties as well as on shape, charge, size, surface modifications and loading method. Here we focused on the potential of using different kinds of nanoparticles and similar nanostructures loaded with various drugs in order to achieve specific targeting and controlled drug release. Thereby, computational modeling on NPs-based drug delivery could help in providing a better understanding of all parts of the delivery system. This review emphasizes recent advances in the usage of various types of nanoparticles and similar nanostructures for drug delivery, aiming to provide a critical review of less toxic and more effective treatment.", journal = "European Journal of Pharmaceutical Sciences", title = "Drug delivery systems based on nanoparticles and related nanostructures", volume = "151", pages = "105412", doi = "10.1016/j.ejps.2020.105412" }
Vujačić Nikezić, A. V., Bondžić, A. M.,& Vasić, V. M.. (2020). Drug delivery systems based on nanoparticles and related nanostructures. in European Journal of Pharmaceutical Sciences, 151, 105412. https://doi.org/10.1016/j.ejps.2020.105412
Vujačić Nikezić AV, Bondžić AM, Vasić VM. Drug delivery systems based on nanoparticles and related nanostructures. in European Journal of Pharmaceutical Sciences. 2020;151:105412. doi:10.1016/j.ejps.2020.105412 .
Vujačić Nikezić, Ana V., Bondžić, Aleksandra M., Vasić, Vesna M., "Drug delivery systems based on nanoparticles and related nanostructures" in European Journal of Pharmaceutical Sciences, 151 (2020):105412, https://doi.org/10.1016/j.ejps.2020.105412 . .