In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope
Abstract
Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM ...bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment.
Keywords:
in silico analysis / neurocardiovascular diseases / neurogenic hypertension / protein-protein interaction / vasovagal syncopeSource:
Frontiers in Neuroscience, 2016, 9, 520-Funding / projects:
- An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41028)
- Application of the EIIP/ISM bioinformatics platform in discovery of novel therapeutic targets and potential therapeutic molecules (RS-MESTD-Basic Research (BR or ON)-173001)
DOI: 10.3389/fnins.2015.00520
ISSN: 1662-453X
WoS: 000368585200001
Scopus: 2-s2.0-84958040917
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VinčaTY - JOUR AU - Bojić, Tijana AU - Perović, Vladimir R. AU - Glišić, Sanja PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/900 AB - Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment. T2 - Frontiers in Neuroscience T1 - In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope VL - 9 SP - 520 DO - 10.3389/fnins.2015.00520 ER -
@article{ author = "Bojić, Tijana and Perović, Vladimir R. and Glišić, Sanja", year = "2016", abstract = "Neurocardiovascular diseases (NCVD) are the leading cause of death in the developed world and will remain so till 2020. In these diseases the pathologically changed nervous control of cardiovascular system has the central role. The actual NCV syndromes are neurogenic hypertension, representing the sympathetically mediated disorder, and vasovagal syncope, which is the vagally mediated disorders. Vasovagal syncope, the disease far from its etiological treatment, could benefit from recruiting and application of antimuscarinic drugs used in other parasympathetic disorders. The informational spectrum method (ISM), a method widely applied for the characterization of protein-protein interactions in the field of immunology, endocrinology and anti HIV drug discovery, was applied for the first time in the analysis of neurogenic hypertension and vasovagal syncope therapeutic targets. In silico analysis revealed the potential involvement of apelin in neurogenic hypertension. Applying the EIIP/ISM bioinformatics concept in investigation of drugs for treatment of vasovagal syncope suggests that 78% of tested antimuscarinic drugs could have anti vasovagal syncope effect. The presented results confirm that ISM is a promissing method for investigation of molecular mechanisms underlying pathophysiological proceses of NCV syndromes and discovery of therapeutics targets for their treatment.", journal = "Frontiers in Neuroscience", title = "In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope", volume = "9", pages = "520", doi = "10.3389/fnins.2015.00520" }
Bojić, T., Perović, V. R.,& Glišić, S.. (2016). In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope. in Frontiers in Neuroscience, 9, 520. https://doi.org/10.3389/fnins.2015.00520
Bojić T, Perović VR, Glišić S. In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope. in Frontiers in Neuroscience. 2016;9:520. doi:10.3389/fnins.2015.00520 .
Bojić, Tijana, Perović, Vladimir R., Glišić, Sanja, "In silico Therapeutics for Neurogenic Hypertension and Vasovagal Syncope" in Frontiers in Neuroscience, 9 (2016):520, https://doi.org/10.3389/fnins.2015.00520 . .