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Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells
dc.creator | Srdić-Rajić, Tatjana | |
dc.creator | Nikolić, Katarina M. | |
dc.creator | Čavić, Milena R. | |
dc.creator | Đokić, Ivana | |
dc.creator | Gemović, Branislava S. | |
dc.creator | Perović, Vladimir R. | |
dc.creator | Veljković, Nevena V. | |
dc.date.accessioned | 2018-03-01T16:37:20Z | |
dc.date.available | 2018-03-01T16:37:20Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0928-0987 | |
dc.identifier.issn | 1879-0720 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/884 | |
dc.description.abstract | Imidazoline I1 receptor signaling is associated with pathways that regulate cell viability leading to varied cell-type specific phenotypes. We demonstrated that the antihypertensive drug rilmenidine, a selective imidazoline I1 receptor agonist, modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells. Rilmenidine acts through a mechanism which involves deactivation of Ras/MAP kinases ERK, p38 and JNK. Moreover, rilmenidine renders K562 cells, which are particularly resistant to chemotherapeutic agents, susceptible to the DNA damaging drug doxorubicin. The rilmenidine co-treatment with doxorubicin reverses G2/M arrest and triggers apoptotic response to DNA damage. Our data offer new insights into the pathways associated with imidazoline I1 receptor activation in K562 cells suggesting rilmenidine as a valuable tool to deepen our understanding of imidazoline I1 receptor signaling in hematologic malignancies and to search for medicinally active agents. (C) 2015 Elsevier B.V. All rights reserved. | en |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.rights | restrictedAccess | en |
dc.source | European Journal of Pharmaceutical Sciences | en |
dc.subject | Rilmenidine | en |
dc.subject | Imidazoline I1 receptor signaling | en |
dc.subject | Apoptosis | en |
dc.subject | Proliferation | en |
dc.subject | K562 | en |
dc.subject | DNA damage | en |
dc.title | Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Николиц, Катарина; Срдиц-Рајиц, Татјана; Дјокиц, Ивана; Гемовић Бранислава; Цавиц, Милена; Перовић Владимир; Вељковић Невена В.; | |
dc.citation.volume | 81 | |
dc.citation.spage | 172 | |
dc.citation.epage | 180 | |
dc.identifier.wos | 000367787700021 | |
dc.identifier.doi | 10.1016/j.ejps.2015.10.017 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 26598394 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-84946239745 |