Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art
Само за регистроване кориснике
2020
Аутори
Medić, BranislavaStojanović, Marko
Stimec, Bojan V.
Divac, Nevena
Savić Vujović, Katarina
Stojanović, Radan
Čolović, Mirjana B.
Krstić, Danijela Z.
Prostran, Milica
Чланак у часопису (Објављена верзија)
,
© 2020 Bentham Science Publishers
Метаподаци
Приказ свих података о документуАпстракт
Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc.... Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers.
Кључне речи:
Lithium / pharmacological effects / mechanism of action of lithium / mechanism of action of lithium in the brain / lithium in preclinical and clinical studies / adverse effects of lithium / drug interactions with lithiumИзвор:
Current Medicinal Chemistry, 2020, 27, 3, 337-351Финансирање / пројекти:
DOI: 10.2174/0929867325666180904124733
ISSN: 0929-8673
PubMed: 30182841
WoS: 000514833000002
Scopus: 2-s2.0-85079910658
Колекције
Институција/група
VinčaTY - JOUR AU - Medić, Branislava AU - Stojanović, Marko AU - Stimec, Bojan V. AU - Divac, Nevena AU - Savić Vujović, Katarina AU - Stojanović, Radan AU - Čolović, Mirjana B. AU - Krstić, Danijela Z. AU - Prostran, Milica PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8838 AB - Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc. Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers. T2 - Current Medicinal Chemistry T1 - Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art VL - 27 IS - 3 SP - 337 EP - 351 DO - 10.2174/0929867325666180904124733 ER -
@article{ author = "Medić, Branislava and Stojanović, Marko and Stimec, Bojan V. and Divac, Nevena and Savić Vujović, Katarina and Stojanović, Radan and Čolović, Mirjana B. and Krstić, Danijela Z. and Prostran, Milica", year = "2020", abstract = "Lithium is the smallest monovalent cation with many different biological effects. Although lithium is present in the pharmacotherapy of psychiatric illnesses for decades, its precise mechanism of action is still not clarified. Today lithium represents first-line therapy for bipolar disorders (because it possesses both antimanic and antidepressant properties) and the adjunctive treatment for major depression (due to its antisuicidal effects). Beside, lithium showed some protective effects in neurological diseases including acute neural injury, chronic degenerative conditions, Alzheimer's disease as well as in treating leucopenia, hepatitis and some renal diseases. Recent evidence suggested that lithium also possesses some anticancer properties due to its inhibition of Glycogen Synthase Kinase 3 beta (GSK3β) which is included in the regulation of a lot of important cellular processes such as: glycogen metabolism, inflammation, immunomodulation, apoptosis, tissue injury, regeneration etc. Although recent evidence suggested a potential utility of lithium in different conditions, its broader use in clinical practice still trails. The reason for this is a narrow therapeutic index of lithium, numerous toxic effects in various organ systems and some clinically relevant interactions with other drugs. Additionally, it is necessary to perform more preclinical as well as clinical studies in order to a precise therapeutic range of lithium, as well as its detailed mechanism of action. The aim of this review is to summarize the current knowledge concerning the pharmacological and toxicological effects of lithium. © 2020 Bentham Science Publishers.", journal = "Current Medicinal Chemistry", title = "Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art", volume = "27", number = "3", pages = "337-351", doi = "10.2174/0929867325666180904124733" }
Medić, B., Stojanović, M., Stimec, B. V., Divac, N., Savić Vujović, K., Stojanović, R., Čolović, M. B., Krstić, D. Z.,& Prostran, M.. (2020). Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art. in Current Medicinal Chemistry, 27(3), 337-351. https://doi.org/10.2174/0929867325666180904124733
Medić B, Stojanović M, Stimec BV, Divac N, Savić Vujović K, Stojanović R, Čolović MB, Krstić DZ, Prostran M. Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art. in Current Medicinal Chemistry. 2020;27(3):337-351. doi:10.2174/0929867325666180904124733 .
Medić, Branislava, Stojanović, Marko, Stimec, Bojan V., Divac, Nevena, Savić Vujović, Katarina, Stojanović, Radan, Čolović, Mirjana B., Krstić, Danijela Z., Prostran, Milica, "Lithium - Pharmacological and Toxicological Aspects: The Current State of the Art" in Current Medicinal Chemistry, 27, no. 3 (2020):337-351, https://doi.org/10.2174/0929867325666180904124733 . .
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