Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications
Нема приказа
Аутори
Zarić, BožidarkaObradović, Milan M.
Trpković, Andreja
Banach, Maciej
Mikhailidis, Dimitri P.
Isenović, Esma R.
Чланак у часопису (Објављена верзија)
,
© 2020 Bentham Science Publishers
Метаподаци
Приказ свих података о документуАпстракт
The endothelium consists of a monolayer of Endothelial Cells (ECs) which form the inner cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the blood and lymph. The endothelium fulfils functions such as vasodilatation, regulation of adhesion, infiltration of leukocytes, inhibition of platelet adhesion, vessel remodeling and lipoprotein metabolism. ECs synthesize and release compounds such as Nitric Oxide (NO), metabolites of arachidonic acid, Reactive Oxygen Species (ROS) and enzymes that degrade the extracellular matrix. Endothelial dysfunction represents a phenotype prone to atherogenesis and may be used as a marker of atherosclerotic risk. Such dysfunction includes impaired synthesis and availability of NO and an imbalance in the relative contribution of endothelial-derived relaxing factors and contracting factors such as endothelin-1 and angiotensin. This dysfunction appears before the earliest anatomic evidence of atherosclerosis and could be a...n important initial step in further development of atherosclerosis. Endothelial dysfunction was historically treated with vitamin C supplementation and L-arginine supplementation. Short term improvement of the expression of adhesion molecule and endothelial function during antioxidant therapy has been observed. Statins are used in the treatment of hyperlipidaemia, a risk factor for cardiovascular disease. Future studies should focus on identifying the mechanisms involved in the beneficial effects of statins on the endothelium. This may help develop drugs specifically aimed at endothelial dysfunction. © 2020 Bentham Science Publishers.
Кључне речи:
Hyperlipidaemia / endothelium / endothelial dysfunction / statins / cardiovascular disease / atherosclerosisИзвор:
Current Medicinal Chemistry, 2020, 27, 7, 1021-1040Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.2174/0929867326666190903112146
ISSN: 0929-8673
PubMed: 31480995
WoS: 000520070100002
Scopus: 2-s2.0-85078128414
Колекције
Институција/група
VinčaTY - JOUR AU - Zarić, Božidarka AU - Obradović, Milan M. AU - Trpković, Andreja AU - Banach, Maciej AU - Mikhailidis, Dimitri P. AU - Isenović, Esma R. PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8811 AB - The endothelium consists of a monolayer of Endothelial Cells (ECs) which form the inner cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the blood and lymph. The endothelium fulfils functions such as vasodilatation, regulation of adhesion, infiltration of leukocytes, inhibition of platelet adhesion, vessel remodeling and lipoprotein metabolism. ECs synthesize and release compounds such as Nitric Oxide (NO), metabolites of arachidonic acid, Reactive Oxygen Species (ROS) and enzymes that degrade the extracellular matrix. Endothelial dysfunction represents a phenotype prone to atherogenesis and may be used as a marker of atherosclerotic risk. Such dysfunction includes impaired synthesis and availability of NO and an imbalance in the relative contribution of endothelial-derived relaxing factors and contracting factors such as endothelin-1 and angiotensin. This dysfunction appears before the earliest anatomic evidence of atherosclerosis and could be an important initial step in further development of atherosclerosis. Endothelial dysfunction was historically treated with vitamin C supplementation and L-arginine supplementation. Short term improvement of the expression of adhesion molecule and endothelial function during antioxidant therapy has been observed. Statins are used in the treatment of hyperlipidaemia, a risk factor for cardiovascular disease. Future studies should focus on identifying the mechanisms involved in the beneficial effects of statins on the endothelium. This may help develop drugs specifically aimed at endothelial dysfunction. © 2020 Bentham Science Publishers. T2 - Current Medicinal Chemistry T1 - Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications VL - 27 IS - 7 SP - 1021 EP - 1040 DO - 10.2174/0929867326666190903112146 ER -
@article{ author = "Zarić, Božidarka and Obradović, Milan M. and Trpković, Andreja and Banach, Maciej and Mikhailidis, Dimitri P. and Isenović, Esma R.", year = "2020", abstract = "The endothelium consists of a monolayer of Endothelial Cells (ECs) which form the inner cellular lining of veins, arteries, capillaries and lymphatic vessels. ECs interact with the blood and lymph. The endothelium fulfils functions such as vasodilatation, regulation of adhesion, infiltration of leukocytes, inhibition of platelet adhesion, vessel remodeling and lipoprotein metabolism. ECs synthesize and release compounds such as Nitric Oxide (NO), metabolites of arachidonic acid, Reactive Oxygen Species (ROS) and enzymes that degrade the extracellular matrix. Endothelial dysfunction represents a phenotype prone to atherogenesis and may be used as a marker of atherosclerotic risk. Such dysfunction includes impaired synthesis and availability of NO and an imbalance in the relative contribution of endothelial-derived relaxing factors and contracting factors such as endothelin-1 and angiotensin. This dysfunction appears before the earliest anatomic evidence of atherosclerosis and could be an important initial step in further development of atherosclerosis. Endothelial dysfunction was historically treated with vitamin C supplementation and L-arginine supplementation. Short term improvement of the expression of adhesion molecule and endothelial function during antioxidant therapy has been observed. Statins are used in the treatment of hyperlipidaemia, a risk factor for cardiovascular disease. Future studies should focus on identifying the mechanisms involved in the beneficial effects of statins on the endothelium. This may help develop drugs specifically aimed at endothelial dysfunction. © 2020 Bentham Science Publishers.", journal = "Current Medicinal Chemistry", title = "Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications", volume = "27", number = "7", pages = "1021-1040", doi = "10.2174/0929867326666190903112146" }
Zarić, B., Obradović, M. M., Trpković, A., Banach, M., Mikhailidis, D. P.,& Isenović, E. R.. (2020). Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications. in Current Medicinal Chemistry, 27(7), 1021-1040. https://doi.org/10.2174/0929867326666190903112146
Zarić B, Obradović MM, Trpković A, Banach M, Mikhailidis DP, Isenović ER. Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications. in Current Medicinal Chemistry. 2020;27(7):1021-1040. doi:10.2174/0929867326666190903112146 .
Zarić, Božidarka, Obradović, Milan M., Trpković, Andreja, Banach, Maciej, Mikhailidis, Dimitri P., Isenović, Esma R., "Endothelial dysfunction in dyslipidaemia: Molecular mechanisms and clinical implications" in Current Medicinal Chemistry, 27, no. 7 (2020):1021-1040, https://doi.org/10.2174/0929867326666190903112146 . .