Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea
Само за регистроване кориснике
2020
Аутори
Jovanović, Svetlana P.Syrgiannis, Zois
Budimir, Milica
Milivojević, Dušan
Jovanović, Dragana J.
Pavlović, Vladimir B.
Papan, Jelena
Bartenwerfer, Malte
Mojsin, Marija
Stevanović, Milena J.
Todorović-Marković, Biljana
Чланак у часопису (Објављена верзија)
,
© 2019
Метаподаци
Приказ свих података о документуАпстракт
Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HR-TEM, SEM-EDS, FTIR, XRD, PL and UV–Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (1O2) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce 1O2 upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the productio...n of the efficient photosensitizer. On the opposite, GQDs-TU are efficient [rad]OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 μg/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. © 2019
Кључне речи:
Graphene quantum dots / Photodynamic therapy / Singlet oxygen / Cytotoxicity / AntioxidantИзвор:
Materials Science and Engineering: C, 2020, 109, 110539-Финансирање / пројекти:
- Танки слојеви једнослојних угљеничних нанотуба и графена за примену у електроници (RS-MESTD-Basic Research (BR or ON)-172003)
- Проучавање сигналних путева и епигенетичких механизама укључених у контролу експресије хуманих SOX гена: даље расветљавање њихове улоге у одређивању судбине и диференцијацији ћелија (RS-MESTD-Basic Research (BR or ON)-173051)
- Bilateral collaboration between the Republic of Serbia and Germany [451-03-01732/2017-09/7]
DOI: 10.1016/j.msec.2019.110539
ISSN: 0928-4931
PubMed: 32229000
WoS: 000527394600048
Scopus: 2-s2.0-85076495597
Институција/група
VinčaTY - JOUR AU - Jovanović, Svetlana P. AU - Syrgiannis, Zois AU - Budimir, Milica AU - Milivojević, Dušan AU - Jovanović, Dragana J. AU - Pavlović, Vladimir B. AU - Papan, Jelena AU - Bartenwerfer, Malte AU - Mojsin, Marija AU - Stevanović, Milena J. AU - Todorović-Marković, Biljana PY - 2020 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8672 AB - Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HR-TEM, SEM-EDS, FTIR, XRD, PL and UV–Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (1O2) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce 1O2 upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient [rad]OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 μg/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. © 2019 T2 - Materials Science and Engineering: C T1 - Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea VL - 109 SP - 110539 DO - 10.1016/j.msec.2019.110539 ER -
@article{ author = "Jovanović, Svetlana P. and Syrgiannis, Zois and Budimir, Milica and Milivojević, Dušan and Jovanović, Dragana J. and Pavlović, Vladimir B. and Papan, Jelena and Bartenwerfer, Malte and Mojsin, Marija and Stevanović, Milena J. and Todorović-Marković, Biljana", year = "2020", abstract = "Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HR-TEM, SEM-EDS, FTIR, XRD, PL and UV–Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (1O2) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce 1O2 upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient [rad]OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 μg/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. © 2019", journal = "Materials Science and Engineering: C", title = "Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea", volume = "109", pages = "110539", doi = "10.1016/j.msec.2019.110539" }
Jovanović, S. P., Syrgiannis, Z., Budimir, M., Milivojević, D., Jovanović, D. J., Pavlović, V. B., Papan, J., Bartenwerfer, M., Mojsin, M., Stevanović, M. J.,& Todorović-Marković, B.. (2020). Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea. in Materials Science and Engineering: C, 109, 110539. https://doi.org/10.1016/j.msec.2019.110539
Jovanović SP, Syrgiannis Z, Budimir M, Milivojević D, Jovanović DJ, Pavlović VB, Papan J, Bartenwerfer M, Mojsin M, Stevanović MJ, Todorović-Marković B. Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea. in Materials Science and Engineering: C. 2020;109:110539. doi:10.1016/j.msec.2019.110539 .
Jovanović, Svetlana P., Syrgiannis, Zois, Budimir, Milica, Milivojević, Dušan, Jovanović, Dragana J., Pavlović, Vladimir B., Papan, Jelena, Bartenwerfer, Malte, Mojsin, Marija, Stevanović, Milena J., Todorović-Marković, Biljana, "Graphene quantum dots as singlet oxygen producer or radical quencher - The matter of functionalization with urea/thiourea" in Materials Science and Engineering: C, 109 (2020):110539, https://doi.org/10.1016/j.msec.2019.110539 . .