Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat
2019
Преузимање 🢃
Аутори
Cvetković, StefanaĐukanović, S.
Mitić-Ćulafić, Dragana
Nastasijević, Branislav J.
Knežević-Vukčević, Jelena
Nikolić, Biljana
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
During high-temperature cooking of protein rich foods, especially meat and fish, heterocyclic aromatic amines can be formed. These amines are a class of potent mutagens that can cause alterations in the structure of DNA and chromosomes. In recent decades, research has been focused on investigating plants and their phytochemicals as potential antimutagens. The aim of this study was to examine the anti-genotoxic effect of methanolic root and leaf extracts of Gentiana lutea against the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) produced in thermally processed meat. To determine the protective potential of extracts, the alkaline comet assay was applied. The results obtained indicated strong anti-genotoxic effect of both extracts against the tested mutagens. The highest inhibition of IQ-induced genotoxicity was recorded for leaf extract (72%). Regarding PhiP, root extract achieved inhibition of 80% of DNA damage, so ...was more successful than leaf extract. The data obtained in this study stimulates further research of G. lutea extracts and its constituents as potential dietary supplements in improving human health. © Published under licence by IOP Publishing Ltd.
Извор:
IOP Conference Series: Earth and Environmental Science, 2019, 333, 1, UNSP 012052-Финансирање / пројекти:
- Биолошки активни природни производи као потенцијални извори нових лекова и дијететских суплемената (RS-MESTD-Basic Research (BR or ON)-172058)
Напомена:
- Conference of 60th International Meat Industry Conference, MEATCON 2019 ; Conference Date: 22-25 September 2019; Conference Code:153290
DOI: 10.1088/1755-1315/333/1/012052
ISSN: 1755-1307
WoS: 000509758800052
Scopus: 2-s2.0-85074665104
Колекције
Институција/група
VinčaTY - CONF AU - Cvetković, Stefana AU - Đukanović, S. AU - Mitić-Ćulafić, Dragana AU - Nastasijević, Branislav J. AU - Knežević-Vukčević, Jelena AU - Nikolić, Biljana PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8627 AB - During high-temperature cooking of protein rich foods, especially meat and fish, heterocyclic aromatic amines can be formed. These amines are a class of potent mutagens that can cause alterations in the structure of DNA and chromosomes. In recent decades, research has been focused on investigating plants and their phytochemicals as potential antimutagens. The aim of this study was to examine the anti-genotoxic effect of methanolic root and leaf extracts of Gentiana lutea against the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) produced in thermally processed meat. To determine the protective potential of extracts, the alkaline comet assay was applied. The results obtained indicated strong anti-genotoxic effect of both extracts against the tested mutagens. The highest inhibition of IQ-induced genotoxicity was recorded for leaf extract (72%). Regarding PhiP, root extract achieved inhibition of 80% of DNA damage, so was more successful than leaf extract. The data obtained in this study stimulates further research of G. lutea extracts and its constituents as potential dietary supplements in improving human health. © Published under licence by IOP Publishing Ltd. C3 - IOP Conference Series: Earth and Environmental Science T1 - Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat VL - 333 IS - 1 SP - UNSP 012052 DO - 10.1088/1755-1315/333/1/012052 ER -
@conference{ author = "Cvetković, Stefana and Đukanović, S. and Mitić-Ćulafić, Dragana and Nastasijević, Branislav J. and Knežević-Vukčević, Jelena and Nikolić, Biljana", year = "2019", abstract = "During high-temperature cooking of protein rich foods, especially meat and fish, heterocyclic aromatic amines can be formed. These amines are a class of potent mutagens that can cause alterations in the structure of DNA and chromosomes. In recent decades, research has been focused on investigating plants and their phytochemicals as potential antimutagens. The aim of this study was to examine the anti-genotoxic effect of methanolic root and leaf extracts of Gentiana lutea against the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) produced in thermally processed meat. To determine the protective potential of extracts, the alkaline comet assay was applied. The results obtained indicated strong anti-genotoxic effect of both extracts against the tested mutagens. The highest inhibition of IQ-induced genotoxicity was recorded for leaf extract (72%). Regarding PhiP, root extract achieved inhibition of 80% of DNA damage, so was more successful than leaf extract. The data obtained in this study stimulates further research of G. lutea extracts and its constituents as potential dietary supplements in improving human health. © Published under licence by IOP Publishing Ltd.", journal = "IOP Conference Series: Earth and Environmental Science", title = "Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat", volume = "333", number = "1", pages = "UNSP 012052", doi = "10.1088/1755-1315/333/1/012052" }
Cvetković, S., Đukanović, S., Mitić-Ćulafić, D., Nastasijević, B. J., Knežević-Vukčević, J.,& Nikolić, B.. (2019). Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat. in IOP Conference Series: Earth and Environmental Science, 333(1), UNSP 012052. https://doi.org/10.1088/1755-1315/333/1/012052
Cvetković S, Đukanović S, Mitić-Ćulafić D, Nastasijević BJ, Knežević-Vukčević J, Nikolić B. Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat. in IOP Conference Series: Earth and Environmental Science. 2019;333(1):UNSP 012052. doi:10.1088/1755-1315/333/1/012052 .
Cvetković, Stefana, Đukanović, S., Mitić-Ćulafić, Dragana, Nastasijević, Branislav J., Knežević-Vukčević, Jelena, Nikolić, Biljana, "Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat" in IOP Conference Series: Earth and Environmental Science, 333, no. 1 (2019):UNSP 012052, https://doi.org/10.1088/1755-1315/333/1/012052 . .