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Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis
dc.creator | Kolić, Ivana | |
dc.creator | Stojković, Ljiljana S. | |
dc.creator | Dinčić, Evica | |
dc.creator | Jovanović, Ivan G. | |
dc.creator | Stanković, Aleksandra | |
dc.creator | Živković, Maja | |
dc.date.accessioned | 2020-05-14T12:20:19Z | |
dc.date.available | 2020-05-14T12:20:19Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0165-5728 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/8618 | |
dc.description.abstract | Leptin (LEP) may contribute to the pathogenesis of multiple sclerosis (MS) by its immunomodulatory, proinflammatory and prooxidant effects. Therefore, plasma LEP levels and mRNA expression of five genes related to the LEP signaling pathway (LEP, LEP receptor (LEPR), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1A), superoxide dismutase 2, tumor necrosis factor-alpha) were investigated in relapsing-remitting MS. In patients (N = 64), compared to healthy subjects (N = 62), relative LEP mRNA levels were significantly increased (p = 0,01), while LEPR and PGC1A mRNA levels were decreased (p = 0,001 and p = 0,04, respectively). Significant positive correlation was observed between LEPR mRNA levels and clinical parameters of MS progression (EDSS, MSSS). © 2019 | en |
dc.language.iso | en | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175085/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41028/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Neuroimmunology | |
dc.subject | Peripheral blood mononuclear cells | en |
dc.subject | Leptin | en |
dc.subject | mRNA expression | en |
dc.subject | Inflammation | en |
dc.subject | Oxidative response | en |
dc.subject | Multiple sclerosis | en |
dc.title | Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Живковић, Маја; Стојковић, Љиљана; Јовановић, Иван; Станковић, Aлександра; Колић, Ивана; Динчић, Евица; | |
dc.rights.holder | © 2019 | |
dc.citation.volume | 338 | |
dc.citation.spage | 577090 | |
dc.identifier.wos | 000508751300005 | |
dc.identifier.doi | 10.1016/j.jneuroim.2019.577090 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 31704454 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85074353466 |
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