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Protective effects of whey on rat liver damage induced by chronic alcohol intake
dc.creator | Radić, Ivan | |
dc.creator | Mijović, Milica | |
dc.creator | Tatalović, Nikola R. | |
dc.creator | Mitić, Miloš | |
dc.creator | Lukić, Vera | |
dc.creator | Joksimović, Bojan | |
dc.creator | Petrović, Zorica | |
dc.creator | Ristić, Siniša | |
dc.creator | Veličković, Stefan | |
dc.creator | Nestorović, Vojkan | |
dc.creator | Ćorac, Aleksandar M. | |
dc.creator | Mirić, Mirjana | |
dc.creator | Adžić, Miroslav | |
dc.creator | Blagojević, Duško P. | |
dc.creator | Popović, Ljiljana M. | |
dc.creator | Janićijević-Hudomal, Snežana | |
dc.date.accessioned | 2020-04-13T13:07:14Z | |
dc.date.available | 2020-04-13T13:07:14Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0960-3271 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/8541 | |
dc.description.abstract | In 2012, alcohol liver disease resulted in 3.3 million—5.9% of global deaths. This study introduced whey protection capacity against chronic alcohol-induced liver injury. Rats were orally administered to 12% ethanol solution in water (ad libitum, average 8.14 g of ethanol/kg body weight (b.w.)/day) alone or combined with whey (per os, 2 g/kg b.w./day). After 6-week treatment, chronic ethanol consumption induced significant histopathological liver changes: congestion, central vein dilation, hepatic portal vein branch dilation, Kupffer cells hyperplasia, fatty liver changes, and hepatocytes focal necrosis. Ethanol significantly increased liver catalase activity and glutathione reductase protein expression without significant effects on antioxidative enzymes: glutathione peroxidase (GPx), copper–zinc-containing superoxide dismutase (CuZnSOD) and manganese-containing superoxide dismutase (MnSOD). Co-treatment with whey significantly attenuated pathohistological changes induced by ethanol ingestion and increased GSH-Px and nuclear factor kappa B (NF-κB) protein expression. Our results showed positive effects of whey on liver chronically exposed to ethanol, which seem to be associated with NF-κB-GPx signaling. © The Author(s) 2019. | en |
dc.language.iso | en | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41029/RS// | |
dc.rights | restrictedAccess | |
dc.source | Human and Experimental Toxicology | en |
dc.subject | Alcohol liver disease | en |
dc.subject | rat | en |
dc.subject | whey | en |
dc.subject | ethanol | en |
dc.subject | antioxidant enzymes | en |
dc.subject | NF-B | en |
dc.title | Protective effects of whey on rat liver damage induced by chronic alcohol intake | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Aджић, Мирослав; Радић, Иван; Мијовић, Милица; Таталовић, Никола Р.; Митић, Милош; Лукић, Вера; Јоксимовић, Бојан; Петровић, Зорица; Несторовић, Војкан; Ћорац, Aлександар М.; Мирић, Мирјана; Благојевић, Душко П.; Поповић, Љиљана М.; Јанићијевић-Худомал, Снежана; Ристић, Синиша; Величковић, Стефан; | |
dc.rights.holder | © The Author(s) 2019 | |
dc.citation.volume | 38 | |
dc.citation.issue | 6 | |
dc.citation.spage | 632 | |
dc.citation.epage | 645 | |
dc.identifier.wos | 000470714400002 | |
dc.identifier.doi | 10.1177/0960327119829518 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 30784321 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85062018247 |
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