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Redox control of vascular biology
dc.creator | Obradović, Milan M. | |
dc.creator | Essack, Magbubah | |
dc.creator | Zafirović, Sonja | |
dc.creator | Sudar-Milovanović, Emina | |
dc.creator | Bajić, Vladan P. | |
dc.creator | Van Neste, Christophe | |
dc.creator | Trpković, Andreja | |
dc.creator | Stanimirović, Julijana | |
dc.creator | Bajić, Vladimir B. | |
dc.creator | Isenović, Esma R. | |
dc.date.accessioned | 2020-02-11T23:07:06Z | |
dc.date.available | 2020-02-11T23:07:06Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0951-6433 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/8486 | |
dc.description.abstract | Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventually lead to cancer and cardiovascular and neurodegenerative diseases. In this review, we focus on redox effects in the vascular system. We pay close attention to the subcompartments of the vascular system (endothelium, smooth muscle cell layer) and give an overview of how redox changes influence those different compartments. We also review the core aspects of redox biology, cardiovascular physiology, and pathophysiology. Moreover, the topic-specific knowledgebase DES-RedoxVasc was used to develop two case studies, one focused on endothelial cells and the other on the vascular smooth muscle cells, as a starting point to possibly extend our knowledge of redox control in vascular biology. © 2019 The Authors. BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology. | en |
dc.language.iso | en | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173033/RS// | |
dc.relation | KAUST [OSR#4129] | |
dc.relation | KAUST Base Research Fund [BAS/1/1606‐01‐01] | |
dc.relation | KAUST Office of Sponsored Research (OSR) [FCC/1/1976‐24‐01] | |
dc.relation | KAUST Office of Sponsored Research (OSR) [FCC/1/1976‐17‐01] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | BioFactors | |
dc.subject | cardiovascular diseases | en |
dc.subject | cardiovascular system | en |
dc.subject | reactive oxygen species | en |
dc.subject | redox | en |
dc.title | Redox control of vascular biology | en |
dc.type | review | en |
dc.rights.license | BY | |
dcterms.abstract | Бајиц, В Б; Обрадовиц, М; Ессацк, М; Зафировиц, С; Трпковиц, A; Станимировиц, Ј; Исеновиц, Е Р; Судар-Миловановиц, Е; Бајиц, В П; Ван Несте, Ц; | |
dc.rights.holder | © 2019 The Authors. BioFactors published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology | |
dc.citation.volume | 46 | |
dc.citation.issue | 2 | |
dc.citation.spage | 246 | |
dc.citation.epage | 262 | |
dc.identifier.wos | 000524885800007 | |
dc.identifier.doi | 10.1002/biof.1559 | |
dc.citation.rank | M22 | |
dc.identifier.pmid | 31483915 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85071758400 | |
dc.identifier.scopus | 2-s2.0-85071758400 | |
dc.identifier.fulltext | https://vinar.vin.bg.ac.rs/bitstream/id/21196/biof.1559.pdf |
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