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dc.creatorĆirić, Ana
dc.creatorMedarević, Đorđe P.
dc.creatorČalija, Bojan
dc.creatorDobričić, Vladimir
dc.creatorMitrić, Miodrag
dc.creatorĐekić, Ljiljana
dc.date.accessioned2020-02-05T13:03:42Z
dc.date.available2020-02-05T13:03:42Z
dc.date.issued2020
dc.identifier.issn0141-8130
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8473
dc.description.abstractThis study investigated the combined influence of pH adjusting agent type (hydrochloric, acetic or lactic acid) and initial pH value (3.6, 4.6, and 5.6) on formation of biocompatible chitosan/xanthan polyelectrolyte complexes (PECs), their characteristics in solid state and influence on in vitro ibuprofen release kinetics. Conductivity measurements and rheological characterization revealed generally higher extent of ionic interactions in PEC dispersions comprising acetic acid and at pH 3.6. Acid type and pH affected significantly the yield and particle size (100–250 μm) of the dried PECs. Differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and powder X-ray diffraction (PXRD) analysis of the solid PECs confirmed exclusively physical (ionic, hydrogen bonds) interactions between chitosan and xanthan gum. PECs prepared with acetic acid at pH 4.6 and 5.6 had enhanced rehydration ability in phosphate buffer pH 7.2, and at PEC-to-drug mass ratio up to 1:2, enabled extended ibuprofen release from hard capsules during 10 h. © 2020 Elsevier B.V.en
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46010/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Biological Macromolecules
dc.subjectChitosanen
dc.subjectIbuprofenen
dc.subjectin vitro drug releaseen
dc.subjectIonic interaction strengthen
dc.subjectPolyelectrolyte complexen
dc.subjectXanthan gumen
dc.titleStudy of chitosan/xanthan gum polyelectrolyte complexes formation, solid state and influence on ibuprofen release kineticsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractМитрић, Миодраг; Чалија, Бојан; Добричић, Владимир; Ђекић, Љиљана; Ћирић, Aна; Медаревић, Ђорђе;
dc.rights.holder© 2020 Elsevier B.V.
dc.citation.volume148
dc.citation.spage942
dc.citation.epage955
dc.identifier.doi10.1016/j.ijbiomac.2020.01.138
dc.citation.rankaM21~
dc.identifier.pmid31954125
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85078267063


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