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dc.creatorSpremo-Potparević, Biljana
dc.creatorBajić, Vladan P.
dc.creatorPerry, George
dc.creatorŽivković, Lada
dc.date.accessioned2018-03-01T16:33:49Z
dc.date.available2018-03-01T16:33:49Z
dc.date.issued2015
dc.identifier.issn1567-2050 (print)
dc.identifier.issn1875-5828 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/844
dc.description.abstractChromosomal alterations as a sign of genetic instability are a feature of Alzheimers disease (AD). Assessment of the genetic instability of non-neuronal cells of AD patients may provide a method to diagnose or monitor prognosis of the disease. Considering the importance of X chromosome alterations in the possible etiology of AD females, we used fluorescent in situ hybridization (FISH) for the centromere region of the X chromosome to determine aneuploidy, for a possible correlation with premature centromere division (PCD, X) in lymphocytes of AD females and age-matched controls. In AD patients, our results showed a marked and significant increase in the frequency of the X chromosome aneuploidy comparing with age matched controls (p LT 0.001). Also, a significant difference was detected in the PCD, X frequency between AD females when compared with age matched controls (p LT 0.001). In addition, a strong (R2=0.97, n=20) and significant (p LT 0.001) correlation was found between the frequency of aneuploidy and PCD, X in the AD group. Our results support the view that AD is a generalized systematic disease where PCD is to be considered as a stable sign of disease leading to aneuploidy.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccessen
dc.sourceCurrent Alzheimer Researchen
dc.subjectAlzheimers diseaseen
dc.subjectaneuploidyen
dc.subjectFISHen
dc.subjectperipheral blood lymphocytesen
dc.subjectPCDen
dc.subjectX chromosomeen
dc.titleAlterations of the X Chromosome in Lymphocytes of Alzheimers Disease Patientsen
dc.typearticleen
dcterms.abstractЗивковиц, Лада; Бајић Владан П.; Спремо-Потпаревиц, Биљана; Перрy, Георге;
dc.citation.volume12
dc.citation.issue10
dc.citation.spage990
dc.citation.epage996
dc.identifier.wos000366135300009
dc.identifier.doi10.2174/1567205012666151027124154
dc.citation.rankM21
dc.identifier.pmid26502819
dc.identifier.scopus2-s2.0-84959457872


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