Alterations of the X Chromosome in Lymphocytes of Alzheimers Disease Patients
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Chromosomal alterations as a sign of genetic instability are a feature of Alzheimers disease (AD). Assessment of the genetic instability of non-neuronal cells of AD patients may provide a method to diagnose or monitor prognosis of the disease. Considering the importance of X chromosome alterations in the possible etiology of AD females, we used fluorescent in situ hybridization (FISH) for the centromere region of the X chromosome to determine aneuploidy, for a possible correlation with premature centromere division (PCD, X) in lymphocytes of AD females and age-matched controls. In AD patients, our results showed a marked and significant increase in the frequency of the X chromosome aneuploidy comparing with age matched controls (p LT 0.001). Also, a significant difference was detected in the PCD, X frequency between AD females when compared with age matched controls (p LT 0.001). In addition, a strong (R2=0.97, n=20) and significant (p LT 0.001) correlation was found between the freque...ncy of aneuploidy and PCD, X in the AD group. Our results support the view that AD is a generalized systematic disease where PCD is to be considered as a stable sign of disease leading to aneuploidy.
Кључне речи:Alzheimers disease / aneuploidy / FISH / peripheral blood lymphocytes / PCD / X chromosome
Извор:Current Alzheimer Research, 2015, 12, 10, 990-996
- Аберације ћелијског циклуса и утицај оксидативног стреса на неуродегенеративне процесе и малигну трансформацију ћелије (RS-173034)
ISSN: 1567-2050 (print); 1875-5828 (electronic)