Antioxidant status and clinicopathological parameters in patients with Parkinson's disease
Antioksidativni status i kliničko-patološki parametri kod obolelih od Parkinsonove bolesti
Autori
Miletić Vukajlović, JadrankaPejić, Snežana
Todorović, Ana
Valenta-Šobot, Ana
Drakulić, Dunja R.
Pavlović, Ivan
Stefanović, Aleksandra
Prostran, Milica
Ilić, Tihomir V.
Stojanov, Marina
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0....001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.
Ključne reči:
parkinson disease / superoxide dismutase / catalase / glutathione / prooxidant-antioxidant balanceIzvor:
Vojnosanitetski pregled, 2019, 77, 7, 724-730Finansiranje / projekti:
- Bazična i kliničko-farmakološka istraživanja mehanizama dejstva i interakcija lekova u nervnom i kardiovaskularnom sistemu (RS-MESTD-Basic Research (BR or ON)-175023)
- Molekularni mehanizmi patofizioloških promena u ćelijama centralnog nervnog sistema i perifernog tkiva kod sisara (RS-MESTD-Basic Research (BR or ON)-173044)
- Ćelijska i molekulska osnova neuroinflamacije: potencijala ciljna mesta za translacionu medicinu i terapiju (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41014)
DOI: 10.2298/VSP180718148M
ISSN: 0042-8450
WoS: 000560134500008
Scopus: 2-s2.0-85078257861
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Miletić Vukajlović, Jadranka AU - Pejić, Snežana AU - Todorović, Ana AU - Valenta-Šobot, Ana AU - Drakulić, Dunja R. AU - Pavlović, Ivan AU - Stefanović, Aleksandra AU - Prostran, Milica AU - Ilić, Tihomir V. AU - Stojanov, Marina PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8407 AB - Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress. T2 - Vojnosanitetski pregled T1 - Antioxidant status and clinicopathological parameters in patients with Parkinson's disease VL - 77 IS - 7 SP - 724 EP - 730 DO - 10.2298/VSP180718148M ER -
@article{ author = "Miletić Vukajlović, Jadranka and Pejić, Snežana and Todorović, Ana and Valenta-Šobot, Ana and Drakulić, Dunja R. and Pavlović, Ivan and Stefanović, Aleksandra and Prostran, Milica and Ilić, Tihomir V. and Stojanov, Marina", year = "2019", abstract = "Backgroun / Aim. Constant production of free radicals and antioxidants (AO) in the cell is a part of normal cellular function. Their imbalance might take a part in pathophysiology of many diseases, including Parkinson’s disease (PD). Evaluation of the disease status, prooxidant-antioxidant balance (PAB) and antioxidants are being widely estimated. The aim of this study was to examine potential interaction between several AO variables (GSH, SOD, CAT and PAB) and clinicopathological features of patients with PD, particularly Hoehn and Yahr (H&Y) stage. Methods. A multivariate analysis of variance (MANOVA) was conducted to test the hypothesis of the mean differences between clinicopathological characteristics (gender, age at examination, duration of the disease, and H&Y stage) and AO variables, compared with age/sex matched healthy controls. The study included 91 patients with idiopatic PD patients and 20 healthy controls. Results. The multivariate effect size was estimated at 0.269, p <0.001, implying that 27.0% of the variance of the dependent variables was accounted for H&Y stage. Univariate tests showed that there were significant differences (p <0.001) across the H&Y stage on all AO variables. The H&Y stage remained significant predictor after controlling for the second variable, the disease duration (p <0.001, η2 = 0.249), and there were still significant differences across the H&Y stage on all variables, with effect size ( η2) ranging from 0.132, p =0.011 (lnGSH) to the still high values of 0.535 (lnPAB), 0.627 (lnSOD) and 0.964 (lnCAT). Conclusion. The results indicate that higher level of oxidative stress in blood of PD patients is possibly related to PD stage. Along with reduction of SOD and GSH level, CAT activity was elevated in comparison to healthy subjects. Furthermore, Pwas shifted toward oxidative stress.", journal = "Vojnosanitetski pregled", title = "Antioxidant status and clinicopathological parameters in patients with Parkinson's disease", volume = "77", number = "7", pages = "724-730", doi = "10.2298/VSP180718148M" }
Miletić Vukajlović, J., Pejić, S., Todorović, A., Valenta-Šobot, A., Drakulić, D. R., Pavlović, I., Stefanović, A., Prostran, M., Ilić, T. V.,& Stojanov, M.. (2019). Antioxidant status and clinicopathological parameters in patients with Parkinson's disease. in Vojnosanitetski pregled, 77(7), 724-730. https://doi.org/10.2298/VSP180718148M
Miletić Vukajlović J, Pejić S, Todorović A, Valenta-Šobot A, Drakulić DR, Pavlović I, Stefanović A, Prostran M, Ilić TV, Stojanov M. Antioxidant status and clinicopathological parameters in patients with Parkinson's disease. in Vojnosanitetski pregled. 2019;77(7):724-730. doi:10.2298/VSP180718148M .
Miletić Vukajlović, Jadranka, Pejić, Snežana, Todorović, Ana, Valenta-Šobot, Ana, Drakulić, Dunja R., Pavlović, Ivan, Stefanović, Aleksandra, Prostran, Milica, Ilić, Tihomir V., Stojanov, Marina, "Antioxidant status and clinicopathological parameters in patients with Parkinson's disease" in Vojnosanitetski pregled, 77, no. 7 (2019):724-730, https://doi.org/10.2298/VSP180718148M . .