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dc.creatorTuszynski, Jack A.
dc.creatorSatarić, Miljko V.
dc.creatorSekulić, Dalibor L.
dc.creatorSatarić, Bogdan M.
dc.creatorZdravković, Slobodan
dc.date.accessioned2019-12-18T09:18:15Z
dc.date.available2019-12-18T09:18:15Z
dc.date.issued2018
dc.identifier.issn0303-2647 (print)
dc.identifier.issn1872-8324 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8397
dc.description.abstractCalcium ions (Ca2+) tune and control numerous diverse aspects of cochlear and vestibular physiological processes. This paper is focused on the Ca2+ control of mechanotransduction in sensory hair cells in the context of polyelectrolyte properties of actin filaments within the hair–bundles of inner ear. These actin filaments appear to serve as efficient pathways for the flow of Ca2+ ions inside stereocilia. We showed how this can be utilized for tuning of force–generating myosin motors. In an established model, we unified the Ca2+ nonlinear dynamics involved in the control of myosin adaptation motors with mechanical displacements of hair–bundles. The model shows that the characteristic time scales fit reasonably well with the available experimental data for spontaneous oscillations in the inner ear. This scenario promises to fill a gap in our understanding of the role of Ca2+ ions in the regulation of processes in the auditory cells of the inner ear. © 2018 Elsevier B.V.en
dc.language.isoen
dc.relationProvincial Secretariat for Higher Education and Scientific Research of AP Vojvodina [114-451-2708/2016-03]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43008/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45010/RS//
dc.relationSerbian Academy of Sciences and Arts
dc.relationNatural Sciences and Engineering Research Council of Canada
dc.rightsrestrictedAccess
dc.sourceBiosystems
dc.subjectActin filamenten
dc.subjectCalcium ion dynamicsen
dc.subjectMyosin motoren
dc.subjectHair cellsen
dc.subjectNonlinear modelen
dc.titleNonlinear calcium ion waves along actin filaments control active hair–bundle motilityen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСекулић, Далибор Л.; Сатарић, Богдан М.; Сатарић, Миљко В.; Здравковић, Слободан; Тусзyнски, Јацк A.;
dc.rights.holder© 2018 Elsevier B.V.
dc.citation.volume173
dc.citation.spage181
dc.citation.epage190
dc.identifier.wos000454965200019
dc.identifier.doi10.1016/j.biosystems.2018.08.006
dc.identifier.pmid30179640
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85053211779


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