Literature-Based Enrichment Insights into Redox Control of Vascular Biology
2019
Аутори
Essack, MagbubahSalhi, Adil
Stanimirović, Julijana
Tifratene, Faroug
Bin Raies, Arwa
Hungler, Arnaud
Uludag, Mahmut
Van Neste, Christophe
Trpković, Andreja
Bajić, Vladan P.
Bajić, Vladimir B.
Isenović, Esma R.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles. ROS overproduction leads to cellular oxidative stress. This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers. In this study, we focus on the redox effects related to vascular systems in mammals. To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature. The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems. It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associati...ons of pairs of such enriched concepts, where associations themselves are statistically enriched. For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc. that allow for insights about different aspects of redox effects and control of processes related to the vascular system. Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc. DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic.
Извор:
Oxidative Medicine and Cellular Longevity, 2019, 2019, 1769437-Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- Аберације ћелијског циклуса и утицај оксидативног стреса на неуродегенеративне процесе и малигну трансформацију ћелије (RS-MESTD-Basic Research (BR or ON)-173034)
- King Abdullah University of Science and Technology (KAUST) Base Research Fund [BAS/1/1606-01-01]
- KAUST Office of Sponsored Research (OSR) Award [FCC/1/1976-24-01]
DOI: 10.1155/2019/1769437
ISSN: 1942-0900; 1942-0994
PubMed: 31223421
WoS: 000469250000001
Scopus: 2-s2.0-85068493861
Колекције
Институција/група
VinčaTY - JOUR AU - Essack, Magbubah AU - Salhi, Adil AU - Stanimirović, Julijana AU - Tifratene, Faroug AU - Bin Raies, Arwa AU - Hungler, Arnaud AU - Uludag, Mahmut AU - Van Neste, Christophe AU - Trpković, Andreja AU - Bajić, Vladan P. AU - Bajić, Vladimir B. AU - Isenović, Esma R. PY - 2019 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8389 AB - In cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles. ROS overproduction leads to cellular oxidative stress. This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers. In this study, we focus on the redox effects related to vascular systems in mammals. To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature. The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems. It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associations of pairs of such enriched concepts, where associations themselves are statistically enriched. For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc. that allow for insights about different aspects of redox effects and control of processes related to the vascular system. Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc. DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic. T2 - Oxidative Medicine and Cellular Longevity T1 - Literature-Based Enrichment Insights into Redox Control of Vascular Biology VL - 2019 SP - 1769437 DO - 10.1155/2019/1769437 ER -
@article{ author = "Essack, Magbubah and Salhi, Adil and Stanimirović, Julijana and Tifratene, Faroug and Bin Raies, Arwa and Hungler, Arnaud and Uludag, Mahmut and Van Neste, Christophe and Trpković, Andreja and Bajić, Vladan P. and Bajić, Vladimir B. and Isenović, Esma R.", year = "2019", abstract = "In cellular physiology and signaling, reactive oxygen species (ROS) play one of the most critical roles. ROS overproduction leads to cellular oxidative stress. This may lead to an irrecoverable imbalance of redox (oxidation-reduction reaction) function that deregulates redox homeostasis, which itself could lead to several diseases including neurodegenerative disease, cardiovascular disease, and cancers. In this study, we focus on the redox effects related to vascular systems in mammals. To support research in this domain, we developed an online knowledge base, DES-RedoxVasc, which enables exploration of information contained in the biomedical scientific literature. The DES-RedoxVasc system analyzed 233399 documents consisting of PubMed abstracts and PubMed Central full-text articles related to different aspects of redox biology in vascular systems. It allows researchers to explore enriched concepts from 28 curated thematic dictionaries, as well as literature-derived potential associations of pairs of such enriched concepts, where associations themselves are statistically enriched. For example, the system allows exploration of associations of pathways, diseases, mutations, genes/proteins, miRNAs, long ncRNAs, toxins, drugs, biological processes, molecular functions, etc. that allow for insights about different aspects of redox effects and control of processes related to the vascular system. Moreover, we deliver case studies about some existing or possibly novel knowledge regarding redox of vascular biology demonstrating the usefulness of DES-RedoxVasc. DES-RedoxVasc is the first compiled knowledge base using text mining for the exploration of this topic.", journal = "Oxidative Medicine and Cellular Longevity", title = "Literature-Based Enrichment Insights into Redox Control of Vascular Biology", volume = "2019", pages = "1769437", doi = "10.1155/2019/1769437" }
Essack, M., Salhi, A., Stanimirović, J., Tifratene, F., Bin Raies, A., Hungler, A., Uludag, M., Van Neste, C., Trpković, A., Bajić, V. P., Bajić, V. B.,& Isenović, E. R.. (2019). Literature-Based Enrichment Insights into Redox Control of Vascular Biology. in Oxidative Medicine and Cellular Longevity, 2019, 1769437. https://doi.org/10.1155/2019/1769437
Essack M, Salhi A, Stanimirović J, Tifratene F, Bin Raies A, Hungler A, Uludag M, Van Neste C, Trpković A, Bajić VP, Bajić VB, Isenović ER. Literature-Based Enrichment Insights into Redox Control of Vascular Biology. in Oxidative Medicine and Cellular Longevity. 2019;2019:1769437. doi:10.1155/2019/1769437 .
Essack, Magbubah, Salhi, Adil, Stanimirović, Julijana, Tifratene, Faroug, Bin Raies, Arwa, Hungler, Arnaud, Uludag, Mahmut, Van Neste, Christophe, Trpković, Andreja, Bajić, Vladan P., Bajić, Vladimir B., Isenović, Esma R., "Literature-Based Enrichment Insights into Redox Control of Vascular Biology" in Oxidative Medicine and Cellular Longevity, 2019 (2019):1769437, https://doi.org/10.1155/2019/1769437 . .