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dc.creatorGlumac, Sofija
dc.creatorPejić, Snežana
dc.creatorKovacevic, R.
dc.creatorDundjerovic, D.
dc.creatorDavidović, Radoslav S.
dc.creatorRistic, D.
dc.creatorSopta, J.
dc.date.accessioned2018-03-01T16:33:02Z
dc.date.available2018-03-01T16:33:02Z
dc.date.issued2015
dc.identifier.issn1676-5680 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/835
dc.description.abstractRhabdomyosarcoma (RMS) is a highly malignant cancer. Over the last two decades, prognosis for RMS patients has significantly improved, with the exception of those in the high-risk group. In order to identify new prognostic factors, we investigated the expression of nestin in RMS cells and its correlation with clinicopathological features and patient outcome. The analysis of overall survival for all patients (N = 30) revealed 1-, 2-, 3-, 4-, and 5-year survival rates of 93.3, 83.3, 66.7, 63.3, and 63.3%, respectively. Nestin overexpression significantly correlated with survival (P = 0.044). Survival of patients with = 50% nestin-positive cells was 90, 70, and 40% after 1, 2, and 3 years, respectively, and remained unchanged until the end of the investigation period. The study group composed of patients exhibiting nestin expression in GT 50% of cells showed 1-, 2-, 3-, and 4-year survival rates of 95, 90, 80, and 75%, respectively, remaining stable at 75% for the fifth year of observation. A nestin-positive expression rate lower than 50% was observed more frequently in older patients (43.60 +/- 27.58 years; P = 0.028). In addition, higher rates of nestin expression were observed in most embryonal RMS specimens and low-grade tumors, in early stages of the disease, and among younger patients. Our results lead us to propose nestin as possible positive prognostic factor in RMS.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.rightsopenAccessen
dc.sourceGenetics and Molecular Researchen
dc.subjectImmunohistochemistryen
dc.subjectNestinen
dc.subjectRhabdomyosarcomaen
dc.subjectSurvivalen
dc.subjectClinicopathological significanceen
dc.titleImmunohistochemical expression of nestin in rhabdomyosarcoma: implications for clinicopathology and patient outcomeen
dc.typearticleen
dcterms.abstractГлумац, С.; Дундјеровиц, Д.; Ковацевиц, Р.; Ристиц, Д.; Сопта, Ј.; Давидовић Радослав; Пејић Снежана;
dc.citation.volume14
dc.citation.issue4
dc.citation.spage14649
dc.citation.epage14659
dc.identifier.wos000365685200051
dc.identifier.doi10.4238/2015.November.18.29
dc.citation.rankM23
dc.identifier.pmid26600525
dc.identifier.scopus2-s2.0-84947567590
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/14230/831.pdf


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