The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications
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2019
Authors
Perić, Marko R.Radović, Magdalena
Mirković, Marija D.
Nikolić, Aleksandar S.
Iskrenović, Predrag
Janković, Drina
Vranješ-Đurić, Sanja
Article (Published version)
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The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe3O4-DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe3O4-DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm(-3). For a better understanding of hyperthermia, the behavior of Fe3O4-DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides Tc-99m and Y-90 was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effect were observed..., thus paving the way for the possible theranostic applications of Fe3O4-DPD MNPs.
Source:
New Journal of Chemistry, 2019, 43, 15, 5932-5939Funding / projects:
- Magnetic and radionuclide labeled nanostructured materials for medical applications (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45015)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
- Diagnostics and Optimization of Plasma Sources Important for Applications (RS-MESTD-Basic Research (BR or ON)-171034)
DOI: 10.1039/C8NJ06478D
ISSN: 1144-0546; 1369-9261
WoS: 000465240500031
Scopus: 2-s2.0-85064107332
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VinčaTY - JOUR AU - Perić, Marko R. AU - Radović, Magdalena AU - Mirković, Marija D. AU - Nikolić, Aleksandar S. AU - Iskrenović, Predrag AU - Janković, Drina AU - Vranješ-Đurić, Sanja PY - 2019 UR - http://xlink.rsc.org/?DOI=C8NJ06478D UR - https://vinar.vin.bg.ac.rs/handle/123456789/8139 AB - The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe3O4-DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe3O4-DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm(-3). For a better understanding of hyperthermia, the behavior of Fe3O4-DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides Tc-99m and Y-90 was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effect were observed, thus paving the way for the possible theranostic applications of Fe3O4-DPD MNPs. T2 - New Journal of Chemistry T1 - The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications VL - 43 IS - 15 SP - 5932 EP - 5939 DO - 10.1039/C8NJ06478D ER -
@article{ author = "Perić, Marko R. and Radović, Magdalena and Mirković, Marija D. and Nikolić, Aleksandar S. and Iskrenović, Predrag and Janković, Drina and Vranješ-Đurić, Sanja", year = "2019", abstract = "The advances in nanotechnology are directed towards the development of new theranostic agents based on magnetic nanoparticles that can be used for both cancer detection and treatment. In this study, 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles (Fe3O4-DPD MNPs) were evaluated for their theranostic application using different methods. The magnetic hyperthermia efficiency of the Fe3O4-DPD MNPs was investigated in saline solution with ionic strengths between 0.05 and 1.0 mol dm(-3). For a better understanding of hyperthermia, the behavior of Fe3O4-DPD MNPs under a non-alternating magnetic field was studied, and the transparency of the sample was measured. Furthermore, the radiotracer method using the radionuclides Tc-99m and Y-90 was applied as a reliable and powerful method for evaluating the in vivo behavior of a nanoprobe; a high radiolabeling yield (>93%), in vitro and in vivo stability of the radiolabeled nanoparticles and high heating effect were observed, thus paving the way for the possible theranostic applications of Fe3O4-DPD MNPs.", journal = "New Journal of Chemistry", title = "The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications", volume = "43", number = "15", pages = "5932-5939", doi = "10.1039/C8NJ06478D" }
Perić, M. R., Radović, M., Mirković, M. D., Nikolić, A. S., Iskrenović, P., Janković, D.,& Vranješ-Đurić, S.. (2019). The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications. in New Journal of Chemistry, 43(15), 5932-5939. https://doi.org/10.1039/C8NJ06478D
Perić MR, Radović M, Mirković MD, Nikolić AS, Iskrenović P, Janković D, Vranješ-Đurić S. The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications. in New Journal of Chemistry. 2019;43(15):5932-5939. doi:10.1039/C8NJ06478D .
Perić, Marko R., Radović, Magdalena, Mirković, Marija D., Nikolić, Aleksandar S., Iskrenović, Predrag, Janković, Drina, Vranješ-Đurić, Sanja, "The analysis of 2,3-dicarboxypropane-1,1-diphosphonic acid-coated magnetite nanoparticles under an external magnetic field and their radiolabeling for possible theranostic applications" in New Journal of Chemistry, 43, no. 15 (2019):5932-5939, https://doi.org/10.1039/C8NJ06478D . .