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A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation
dc.creator | Metlaš, Radmila | |
dc.creator | Srdić-Rajić, Tatjana | |
dc.date.accessioned | 2019-06-24T07:05:30Z | |
dc.date.available | 2019-06-24T07:05:30Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 1139-6121 | |
dc.identifier.issn | 1698-6997 | |
dc.identifier.uri | http://www.aidsreviews.com/resumen.php?id=1472 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/8128 | |
dc.description.abstract | The goal of this report was to propose a model, wherein synergy between the B-cell antigen receptor (BCR) and toll-like receptor (TLR) signaling is involved in the selection of the B-cell precursors of HIV-1 broadly neutralizing antibodies (bnAbs) with long heavy chain complementarity determining regions 3, from immature/ transitional B cells. The model predicts the involvement of Ab/HIV-1 complexes in a way that Ab from the complex binds both BCRs and HIV-1, while on internalization of HIV-1 TLR ligands such as CpG motifs interacts with TLR9. The result of BCR and TLR9 orchestrated signaling is a formation of somatically mutated memory B cells potential precursors of bnAbs. Generated memory B cells continuously exposed to different Ab/HIV-1 complexes can elicit specific bnAb by stochastic somatic hypermutation rather than in the Darwinian process. This new view of the interaction between Ab/HIV-1 complexes and immune system, leading to affinity maturation of the bnAbs in the absence of nominal HIV-1 antigen and BCR interaction, may have implication for the vaccine designed and passive immunization. © 2019, Publicaciones Permanyer. All rights reserved. | en |
dc.language.iso | en | |
dc.rights | restrictedAccess | |
dc.source | Aids Reviews | |
dc.subject | HIV-1 broadly neutralizing antibodies | en |
dc.subject | Precursor of B-cell antigen receptor for broadly neutralizing antibodies | en |
dc.subject | Toll-like receptor | en |
dc.subject | Membrane proximal external region | en |
dc.title | A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Срдић-Рајић, Татјана; Метлаш, Радмила; | |
dc.citation.volume | 21 | |
dc.citation.issue | 1 | |
dc.citation.spage | 23 | |
dc.citation.epage | 27 | |
dc.identifier.wos | 000461543800004 | |
dc.identifier.doi | 10.24875/AIDSRev.19000028 | |
dc.citation.rank | M23 | |
dc.identifier.pmid | 30899117 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85063686638 |
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