A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation
Апстракт
The goal of this report was to propose a model, wherein synergy between the B-cell antigen receptor (BCR) and toll-like receptor (TLR) signaling is involved in the selection of the B-cell precursors of HIV-1 broadly neutralizing antibodies (bnAbs) with long heavy chain complementarity determining regions 3, from immature/ transitional B cells. The model predicts the involvement of Ab/HIV-1 complexes in a way that Ab from the complex binds both BCRs and HIV-1, while on internalization of HIV-1 TLR ligands such as CpG motifs interacts with TLR9. The result of BCR and TLR9 orchestrated signaling is a formation of somatically mutated memory B cells potential precursors of bnAbs. Generated memory B cells continuously exposed to different Ab/HIV-1 complexes can elicit specific bnAb by stochastic somatic hypermutation rather than in the Darwinian process. This new view of the interaction between Ab/HIV-1 complexes and immune system, leading to affinity maturation of the bnAbs in the absence o...f nominal HIV-1 antigen and BCR interaction, may have implication for the vaccine designed and passive immunization. © 2019, Publicaciones Permanyer. All rights reserved.
Кључне речи:
HIV-1 broadly neutralizing antibodies / Precursor of B-cell antigen receptor for broadly neutralizing antibodies / Toll-like receptor / Membrane proximal external regionИзвор:
Aids Reviews, 2019, 21, 1, 23-27
DOI: 10.24875/AIDSRev.19000028
ISSN: 1139-6121; 1698-6997
PubMed: 30899117
WoS: 000461543800004
Scopus: 2-s2.0-85063686638
Колекције
Институција/група
VinčaTY - JOUR AU - Metlaš, Radmila AU - Srdić-Rajić, Tatjana PY - 2019 UR - http://www.aidsreviews.com/resumen.php?id=1472 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8128 AB - The goal of this report was to propose a model, wherein synergy between the B-cell antigen receptor (BCR) and toll-like receptor (TLR) signaling is involved in the selection of the B-cell precursors of HIV-1 broadly neutralizing antibodies (bnAbs) with long heavy chain complementarity determining regions 3, from immature/ transitional B cells. The model predicts the involvement of Ab/HIV-1 complexes in a way that Ab from the complex binds both BCRs and HIV-1, while on internalization of HIV-1 TLR ligands such as CpG motifs interacts with TLR9. The result of BCR and TLR9 orchestrated signaling is a formation of somatically mutated memory B cells potential precursors of bnAbs. Generated memory B cells continuously exposed to different Ab/HIV-1 complexes can elicit specific bnAb by stochastic somatic hypermutation rather than in the Darwinian process. This new view of the interaction between Ab/HIV-1 complexes and immune system, leading to affinity maturation of the bnAbs in the absence of nominal HIV-1 antigen and BCR interaction, may have implication for the vaccine designed and passive immunization. © 2019, Publicaciones Permanyer. All rights reserved. T2 - Aids Reviews T1 - A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation VL - 21 IS - 1 SP - 23 EP - 27 DO - 10.24875/AIDSRev.19000028 ER -
@article{ author = "Metlaš, Radmila and Srdić-Rajić, Tatjana", year = "2019", abstract = "The goal of this report was to propose a model, wherein synergy between the B-cell antigen receptor (BCR) and toll-like receptor (TLR) signaling is involved in the selection of the B-cell precursors of HIV-1 broadly neutralizing antibodies (bnAbs) with long heavy chain complementarity determining regions 3, from immature/ transitional B cells. The model predicts the involvement of Ab/HIV-1 complexes in a way that Ab from the complex binds both BCRs and HIV-1, while on internalization of HIV-1 TLR ligands such as CpG motifs interacts with TLR9. The result of BCR and TLR9 orchestrated signaling is a formation of somatically mutated memory B cells potential precursors of bnAbs. Generated memory B cells continuously exposed to different Ab/HIV-1 complexes can elicit specific bnAb by stochastic somatic hypermutation rather than in the Darwinian process. This new view of the interaction between Ab/HIV-1 complexes and immune system, leading to affinity maturation of the bnAbs in the absence of nominal HIV-1 antigen and BCR interaction, may have implication for the vaccine designed and passive immunization. © 2019, Publicaciones Permanyer. All rights reserved.", journal = "Aids Reviews", title = "A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation", volume = "21", number = "1", pages = "23-27", doi = "10.24875/AIDSRev.19000028" }
Metlaš, R.,& Srdić-Rajić, T.. (2019). A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation. in Aids Reviews, 21(1), 23-27. https://doi.org/10.24875/AIDSRev.19000028
Metlaš R, Srdić-Rajić T. A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation. in Aids Reviews. 2019;21(1):23-27. doi:10.24875/AIDSRev.19000028 .
Metlaš, Radmila, Srdić-Rajić, Tatjana, "A Model for Potential B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies Selection and Antibody Affinity Maturation" in Aids Reviews, 21, no. 1 (2019):23-27, https://doi.org/10.24875/AIDSRev.19000028 . .