Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates
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2018
Authors
Jokanović, Vukoman R.Čolović, Božana M.
Prokić, Bogomir Bolka
Tomanović, Nada
Popović Bajić, Marijana
Živković, Slavoljub
Article (Published version)
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As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.
Source:
Advances in Materials Science and Engineering, 2018, 2018, 1-6Funding / projects:
- Chemical and structural designing of nanomaterials for application in medicine and tissue engineering (RS-MESTD-Basic Research (BR or ON)-172026)
DOI: 10.1155/2018/8493439
ISSN: 1687-8434; 1687-8442
WoS: 000448572100001
Scopus: 2-s2.0-85062881629
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https://www.hindawi.com/journals/amse/2018/8493439/https://vinar.vin.bg.ac.rs/handle/123456789/8061
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VinčaTY - JOUR AU - Jokanović, Vukoman R. AU - Čolović, Božana M. AU - Prokić, Bogomir Bolka AU - Tomanović, Nada AU - Popović Bajić, Marijana AU - Živković, Slavoljub PY - 2018 UR - https://www.hindawi.com/journals/amse/2018/8493439/ UR - https://vinar.vin.bg.ac.rs/handle/123456789/8061 AB - As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment. T2 - Advances in Materials Science and Engineering T1 - Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates VL - 2018 SP - 1 EP - 6 DO - 10.1155/2018/8493439 ER -
@article{ author = "Jokanović, Vukoman R. and Čolović, Božana M. and Prokić, Bogomir Bolka and Tomanović, Nada and Popović Bajić, Marijana and Živković, Slavoljub", year = "2018", abstract = "As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.", journal = "Advances in Materials Science and Engineering", title = "Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates", volume = "2018", pages = "1-6", doi = "10.1155/2018/8493439" }
Jokanović, V. R., Čolović, B. M., Prokić, B. B., Tomanović, N., Popović Bajić, M.,& Živković, S.. (2018). Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates. in Advances in Materials Science and Engineering, 2018, 1-6. https://doi.org/10.1155/2018/8493439
Jokanović VR, Čolović BM, Prokić BB, Tomanović N, Popović Bajić M, Živković S. Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates. in Advances in Materials Science and Engineering. 2018;2018:1-6. doi:10.1155/2018/8493439 .
Jokanović, Vukoman R., Čolović, Božana M., Prokić, Bogomir Bolka, Tomanović, Nada, Popović Bajić, Marijana, Živković, Slavoljub, "Subchronic Systemic Toxicity of New Endodontic Material Based on Calcium Hydroxyapatite and Calcium Silicates" in Advances in Materials Science and Engineering, 2018 (2018):1-6, https://doi.org/10.1155/2018/8493439 . .