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dc.creatorTošić, Jelena
dc.creatorStanojević, Željka
dc.creatorVidičević, Sašenka
dc.creatorIsaković, Aleksandra J.
dc.creatorĆirić, Darko
dc.creatorMartinović, Tamara
dc.creatorKravić-Stevović, Tamara K.
dc.creatorBumbaširević, Vladimir Ž.
dc.creatorPaunović, Verica G.
dc.creatorJovanović, Svetlana P.
dc.creatorTodorović-Marković, Biljana
dc.creatorMarković, Zoran M.
dc.creatorDanko, Martin
dc.creatorMičušik, Matej
dc.creatorSpitalsky, Zdenko
dc.creatorTrajković, Vladimir S.
dc.date.accessioned2019-02-06T12:24:38Z
dc.date.available2019-02-06T12:24:38Z
dc.date.issued2019
dc.identifier.issn0028-3908 (print)
dc.identifier.urihttps://linkinghub.elsevier.com/retrieve/pii/S0028390818308621
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/8015
dc.description.abstractWe investigated the therapeutic capacity of nano-sized graphene sheets, called graphene quantum dots (GQD), in experimental autoimmune encephalomyelitis (EAE), an animal model of immune-mediated central nervous system (CNS) damage. Intraperitoneally administered GQD (10 mg/kg/day) accumulated in the lymph node and CNS cells of Dark Agouti rats in which EAE was induced by immunization with spinal cord homogenate in complete Freund's adjuvant. GQD significantly reduced clinical signs of EAE when applied throughout the course of the disease (day 0–32), while the protection was less pronounced if the treatment was limited to the induction (day 0–7 post-immunization) or effector (from day 8 onwards) phase of the disease. GQD treatment diminished immune infiltration, demyelination, axonal damage, and apoptotic death in the CNS of EAE animals. GQD also reduced the numbers of interferon-γ-expressing T helper (Th)1 cells, as well as the expression of Th1 transcription factor T-bet and proinflammatory cytokines tumor necrosis factor, interleukin-1, and granulocyte-macrophage colony-stimulating factor in the lymph nodes and CNS immune infitrates. The protective effect of GQD in EAE was associated with the activation of p38 and p42/44 mitogen-activated protein kinases (MAPK) and Akt in the lymph nodes and/or CNS. Finally, GQD protected oligodendrocytes and neurons from T cell-mediated damage in the in vitro conditions. Collectively, these data demonstrate the ability of GQD to gain access to both immune and CNS cells during neuroinflammation, and to alleviate immune-mediated CNS damage by modulating MAPK/Akt signaling and encephalitogenic Th1 immune response. © 2018 Elsevier Ltden
dc.language.isoen
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172003/RS//
dc.rightsrestrictedAccess
dc.sourceNeuropharmacology
dc.subjectGraphene quantum dotsen
dc.subjectNeuroinflammationen
dc.subjectDemyelinationen
dc.subjectT cellsen
dc.subjectInterferon-γen
dc.titleGraphene quantum dots inhibit T cell-mediated neuroinflammation in ratsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractКравић-Стевовић, Тамара; Бумбаширевић, Владимир; Пауновић, Верица; Јовановић, Светлана; Марковић, Зоран; Спиталскy, Зденко; Трајковић, Владимир; Тодоровић-Марковић, Биљана; Данко, Мартин; Мичушик, Матеј; Тошић, Јелена; Станојевић, Жељка; Видичевић, Сашенка; Исаковић, Aлександра; Ћирић, Дарко; Мартиновић, Тамара;
dc.rights.holder© 2018 Elsevier Ltd
dc.citation.volume146
dc.citation.spage95
dc.citation.epage108
dc.identifier.wos000457663900010
dc.identifier.doi10.1016/j.neuropharm.2018.11.030
dc.identifier.pmid30471296
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85059315239


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