Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation
Само за регистроване кориснике
2019
Аутори
Perović, MilanSudar-Milovanović, Emina
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Simonović, Ema D.
Resanović, Ivana
![](/themes/MirageVinar/images/orcid.png)
Draganić, Veselin D.
Radaković, Jovana D.
Soldatović, Ivan A.
![](/themes/MirageVinar/images/orcid.png)
Isenović, Esma R.
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Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
Controlled ovarian stimulation (COS) is used to augment the number of retrieved oocytes in in vitro fertilization (IVF). Follicular fluid (FF) contributes significantly to oocyte quality. Since the FF is composed of follicular secretions and plasma exudation, it reflects alterations in granulosa and thecal cells secretion as well as changes in the level of plasma constituents. Phospholipids (PL) and free fatty acids (FFA) are important constituents of both, FF and serum. Our hypothesis is that COS affects the level of PL and FFA in serum. Furthermore, since the level of PL and FFA in FF partially depends on their levels in serum, as a collaterally of our hypothesis is that the existing level of PL and FFA in serum correlates with the levels of PL and FFA in FF, and that the dose of applied gonadotropins during COS will correlate with the levels of PL and FFA in serum and FF. In addition, we assume that the level of PL and FFA in serum and in FF after COS will correlate with the retriev...ed number of GQ oocytes, one of the most important outcomes of COS.. © 2018
Кључне речи:
In vitro fertilization / Oocyte retrieval / Follicular fluid / Phospholipids / Free fatty acidsИзвор:
Medical Hypotheses, 2019, 123, 30-34Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
DOI: 10.1016/j.mehy.2018.11.021
ISSN: 0306-9877
WoS: 000458594400009
Scopus: 2-s2.0-85058691152
URI
https://linkinghub.elsevier.com/retrieve/pii/S0306987718310892https://vinar.vin.bg.ac.rs/handle/123456789/8006
Колекције
Институција/група
VinčaTY - JOUR AU - Perović, Milan AU - Sudar-Milovanović, Emina AU - Simonović, Ema D. AU - Resanović, Ivana AU - Draganić, Veselin D. AU - Radaković, Jovana D. AU - Soldatović, Ivan A. AU - Isenović, Esma R. PY - 2019 UR - https://linkinghub.elsevier.com/retrieve/pii/S0306987718310892 UR - https://vinar.vin.bg.ac.rs/handle/123456789/8006 AB - Controlled ovarian stimulation (COS) is used to augment the number of retrieved oocytes in in vitro fertilization (IVF). Follicular fluid (FF) contributes significantly to oocyte quality. Since the FF is composed of follicular secretions and plasma exudation, it reflects alterations in granulosa and thecal cells secretion as well as changes in the level of plasma constituents. Phospholipids (PL) and free fatty acids (FFA) are important constituents of both, FF and serum. Our hypothesis is that COS affects the level of PL and FFA in serum. Furthermore, since the level of PL and FFA in FF partially depends on their levels in serum, as a collaterally of our hypothesis is that the existing level of PL and FFA in serum correlates with the levels of PL and FFA in FF, and that the dose of applied gonadotropins during COS will correlate with the levels of PL and FFA in serum and FF. In addition, we assume that the level of PL and FFA in serum and in FF after COS will correlate with the retrieved number of GQ oocytes, one of the most important outcomes of COS.. © 2018 T2 - Medical Hypotheses T1 - Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation VL - 123 SP - 30 EP - 34 DO - 10.1016/j.mehy.2018.11.021 ER -
@article{ author = "Perović, Milan and Sudar-Milovanović, Emina and Simonović, Ema D. and Resanović, Ivana and Draganić, Veselin D. and Radaković, Jovana D. and Soldatović, Ivan A. and Isenović, Esma R.", year = "2019", abstract = "Controlled ovarian stimulation (COS) is used to augment the number of retrieved oocytes in in vitro fertilization (IVF). Follicular fluid (FF) contributes significantly to oocyte quality. Since the FF is composed of follicular secretions and plasma exudation, it reflects alterations in granulosa and thecal cells secretion as well as changes in the level of plasma constituents. Phospholipids (PL) and free fatty acids (FFA) are important constituents of both, FF and serum. Our hypothesis is that COS affects the level of PL and FFA in serum. Furthermore, since the level of PL and FFA in FF partially depends on their levels in serum, as a collaterally of our hypothesis is that the existing level of PL and FFA in serum correlates with the levels of PL and FFA in FF, and that the dose of applied gonadotropins during COS will correlate with the levels of PL and FFA in serum and FF. In addition, we assume that the level of PL and FFA in serum and in FF after COS will correlate with the retrieved number of GQ oocytes, one of the most important outcomes of COS.. © 2018", journal = "Medical Hypotheses", title = "Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation", volume = "123", pages = "30-34", doi = "10.1016/j.mehy.2018.11.021" }
Perović, M., Sudar-Milovanović, E., Simonović, E. D., Resanović, I., Draganić, V. D., Radaković, J. D., Soldatović, I. A.,& Isenović, E. R.. (2019). Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation. in Medical Hypotheses, 123, 30-34. https://doi.org/10.1016/j.mehy.2018.11.021
Perović M, Sudar-Milovanović E, Simonović ED, Resanović I, Draganić VD, Radaković JD, Soldatović IA, Isenović ER. Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation. in Medical Hypotheses. 2019;123:30-34. doi:10.1016/j.mehy.2018.11.021 .
Perović, Milan, Sudar-Milovanović, Emina, Simonović, Ema D., Resanović, Ivana, Draganić, Veselin D., Radaković, Jovana D., Soldatović, Ivan A., Isenović, Esma R., "Hypothesis regarding the effects of gonadotropins on the level of free fatty acids and phospholipids in serum and follicular fluid during controlled ovarian stimulation" in Medical Hypotheses, 123 (2019):30-34, https://doi.org/10.1016/j.mehy.2018.11.021 . .