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Brain Sub/Region-Specific Effects of Olanzapine on c-Fos Expression of Chronically Socially Isolated Rats
dc.creator | Stanisavljević, Andrijana | |
dc.creator | Perić, Ivana | |
dc.creator | Gass, Peter | |
dc.creator | Inta, Dragos | |
dc.creator | Lang, Undine E. | |
dc.creator | Borgwardt, Stefan | |
dc.creator | Filipović, Dragana | |
dc.date.accessioned | 2018-12-12T08:37:59Z | |
dc.date.available | 2018-12-12T08:37:59Z | |
dc.date.issued | 2019 | |
dc.identifier.issn | 0306-4522 | |
dc.identifier.uri | https://linkinghub.elsevier.com/retrieve/pii/S0306452218307395 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/7976 | |
dc.description.abstract | Olanzapine (Olz) is an atypical antipsychotic used to treat depression, anxiety and schizophrenia, which can be caused by chronic psychosocial stress. c-Fos protein expression has been used as an indirect marker of neuronal activity in response to various forms of stress or pharmacological treatments. We examined the effects of a 3-week treatment of Olz (7.5 mg/kg/day) on c-Fos protein expression in stress-relevant brain sub/regions, its relationship with isolation-induced behavioral changes, and potential sites of Olz action on control and male rats exposed to 6 weeks of chronic social isolation (CSIS), an animal model of depression. Olz treatment reversed depression- and anxiety-like behaviors induced by CSIS and suppressed a CSIS-induced increase in the number of c-Fos-positive cells in subregions of the dorsal hippocampus, ventral (v) DG, retrosplenial cortex, and medial prefrontal cortex. In contrast, no change in c-Fos expression was seen in the CA3v, amygdala and thalamic, hypothalamic or striatal subregions in Olz-treated CSIS rats, suggesting different brain sub/regions’ susceptibility to Olz. An increased number of c-Fos-positive cells in the CA1v, amygdala and thalamic, hypothalamic and striatal subregions in controls as well as in the CA1v and subregion of the hypothalamus and nucleus accumbens in Olz-treated CSIS rats was found. Results suggest the activation of brain sub/regions following CSIS that may be involved in depressive and anxiety-like behaviors. Olz treatment showed region-specific effects on neuronal activation. Our data contribute to a better understanding of the mechanisms underlying the CSIS response and potential brain targets of Olz in socially isolated rats. © 2018 IBRO | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS// | |
dc.relation | Deutsche Forschungsgemeinschaft [IN168/3-1] | |
dc.rights | restrictedAccess | |
dc.source | Neuroscience | |
dc.subject | depression- and anxiety-like behaviors | en |
dc.subject | social isolation | en |
dc.subject | C-fos | en |
dc.subject | olanzapine | en |
dc.subject | brain sub/regions | en |
dc.title | Brain Sub/Region-Specific Effects of Olanzapine on c-Fos Expression of Chronically Socially Isolated Rats | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Ланг, Ундине Е; Станисављевић, Aндријана; Перић, Ивана; Гасс, Петер; Инта, Драгос; Боргwардт, Стефан; Филиповић, Драгана; | |
dc.rights.holder | © 2018 IBRO | |
dc.citation.volume | 396 | |
dc.citation.spage | 46 | |
dc.citation.epage | 65 | |
dc.identifier.wos | 000454334500006 | |
dc.identifier.doi | 10.1016/j.neuroscience.2018.11.015 | |
dc.citation.rank | M22 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85057293767 |
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