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dc.creatorStanisavljević, Andrijana
dc.creatorPerić, Ivana
dc.creatorGass, Peter
dc.creatorInta, Dragos
dc.creatorLang, Undine E.
dc.creatorBorgwardt, Stefan
dc.creatorFilipović, Dragana
dc.date.accessioned2018-12-12T08:37:59Z
dc.date.available2018-12-12T08:37:59Z
dc.date.issued2019
dc.identifier.issn0306-4522 (print)
dc.identifier.urihttps://linkinghub.elsevier.com/retrieve/pii/S0306452218307395
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7976
dc.description.abstractOlanzapine (Olz) is an atypical antipsychotic used to treat depression, anxiety and schizophrenia, which can be caused by chronic psychosocial stress. c-Fos protein expression has been used as an indirect marker of neuronal activity in response to various forms of stress or pharmacological treatments. We examined the effects of a 3-week treatment of Olz (7.5 mg/kg/day) on c-Fos protein expression in stress-relevant brain sub/regions, its relationship with isolation-induced behavioral changes, and potential sites of Olz action on control and male rats exposed to 6 weeks of chronic social isolation (CSIS), an animal model of depression. Olz treatment reversed depression- and anxiety-like behaviors induced by CSIS and suppressed a CSIS-induced increase in the number of c-Fos-positive cells in subregions of the dorsal hippocampus, ventral (v) DG, retrosplenial cortex, and medial prefrontal cortex. In contrast, no change in c-Fos expression was seen in the CA3v, amygdala and thalamic, hypothalamic or striatal subregions in Olz-treated CSIS rats, suggesting different brain sub/regions’ susceptibility to Olz. An increased number of c-Fos-positive cells in the CA1v, amygdala and thalamic, hypothalamic and striatal subregions in controls as well as in the CA1v and subregion of the hypothalamus and nucleus accumbens in Olz-treated CSIS rats was found. Results suggest the activation of brain sub/regions following CSIS that may be involved in depressive and anxiety-like behaviors. Olz treatment showed region-specific effects on neuronal activation. Our data contribute to a better understanding of the mechanisms underlying the CSIS response and potential brain targets of Olz in socially isolated rats. © 2018 IBRO
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS//
dc.relationDeutsche Forschungsgemeinschaft [IN168/3-1]
dc.rightsrestrictedAccess
dc.sourceNeuroscience
dc.subjectdepression- and anxiety-like behaviorsen
dc.subjectsocial isolationen
dc.subjectC-fosen
dc.subjectolanzapineen
dc.subjectbrain sub/regionsen
dc.titleBrain Sub/Region-Specific Effects of Olanzapine on c-Fos Expression of Chronically Socially Isolated Ratsen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractЛанг, Ундине Е; Станисављевић, Aндријана; Перић, Ивана; Гасс, Петер; Инта, Драгос; Боргwардт, Стефан; Филиповић, Драгана;
dc.rights.holder© 2018 IBRO
dc.citation.volume396
dc.citation.spage46
dc.citation.epage65
dc.identifier.doi10.1016/j.neuroscience.2018.11.015
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85057293767


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