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dc.creatorĐorđević, Ana
dc.creatorDekleva, Milica
dc.creatorŽivković, Maja
dc.creatorStanković, Aleksandra
dc.creatorMarković-Nikolić, Nataša
dc.creatorAlavantić, Dragan
dc.creatorĐurić, Tamara
dc.date.accessioned2018-12-03T13:18:16Z
dc.date.available2018-12-03T13:18:16Z
dc.date.issued2018
dc.identifier.issn0301-4851 (print)
dc.identifier.issn1573-4978 (electronic)
dc.identifier.urihttp://link.springer.com/10.1007/s11033-018-4384-4
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7958
dc.description.abstractPost-infarct left ventricular remodeling (LVR) process increases the risk of heart failure (HF). Circulating galectin-3 has been associated with fibrosis, inflammation and cardiac dysfunction during the remodeling process after myocardial infarction (MI). The aims of this prospective case study were to investigate the association of potentially functional variants in the vicinity of LGALS-3 locus, rs2274273 and rs17128183 with maladaptive LVR and whether these variants could affect LGALS-3 mRNA expression in peripheral blood mononuclear cells of patients 6 months after the first MI. This study encompassed 167 patients with acute MI that were followed up for 6 months. Evidence of LVR was obtained by repeated 2D Doppler echocardiography. Rs2274273, rs17128183 and LGALS-3 mRNA expression were detected by TaqMan® technology. Rs2274273 and rs17128183 rare allele bearing genotypes, according to the dominant model (CT+TT vs. CC and AG+GG vs. AA, respectively), were significantly and independently associated with maladaptive LVR (adjusted OR = 3.02, P = 0.016; adjusted OR = 3.14, P = 0.019, respectively) and higher LGALS-3 mRNA expression (fold induction 1.203, P = 0.03 and 1.214, P = 0.03, respectively). Our exploratory results suggest that rs2274273 and rs17128183 variants affect LGALS-3 mRNA and bear the risk for maladaptive LVR post-MI remodeling. Further replication and validation in a larger group of patients is inevitable. © 2018, Springer Nature B.V.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41028/RS//
dc.rightsrestrictedAccess
dc.sourceMolecular Biology Reports
dc.subjectRs2274273en
dc.subjectRs17128183en
dc.subjectLGALS-3 mRNAen
dc.subjectMyocardial infarctionen
dc.subjectLeft ventricular remodelingen
dc.titleLeft ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective studyen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractДеклева, Милица; Дјордјевиц, Aна; Зивковиц, Маја; Станковиц, Aлександра; Марковиц Николиц, Натаса; Aлавантиц, Драган; Дјуриц, Тамара;
dc.rights.holder© 2018, Springer Nature B.V
dc.citation.volume45
dc.citation.issue6
dc.citation.spage2227
dc.citation.epage2236
dc.identifier.wos000452543200064
dc.identifier.doi10.1007/s11033-018-4384-4
dc.identifier.pmid30229476
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85053519052


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