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dc.creatorDinčić, Marko
dc.creatorKrstić, Danijela Z.
dc.creatorČolović, Mirjana B.
dc.creatorNešović Ostojić, Jelena
dc.creatorKovačević, Sanjin
dc.creatorDe Luka, Silvio R.
dc.creatorĐorđević, Drago M.
dc.creatorĆirković, Saša
dc.creatorBrkić, Predrag
dc.creatorTodorović, Jasna
dc.date.accessioned2018-12-03T13:17:56Z
dc.date.available2018-12-03T13:17:56Z
dc.date.issued2018
dc.identifier.issn0955-3002 (print)
dc.identifier.issn1362-3095 (electronic)
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/09553002.2018.1518611
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7957
dc.description.abstractPurpose: It is considered that exposure to static magnetic fields (SMF) may have both detrimental and therapeutic effect, but the mechanism of SMF influence on the living organisms is not well understood. Since the adenosine triphosphatases (ATPases) and acetylcholinesterase (AChE) are involved in both physiological and pathological processes, the modulation of Na+/K+-ATPase, ecto-ATPases and AChE activities, as well as oxidative stress responses were followed in synaptosomes isolated from rats after chronic exposure toward differently oriented SMF. Material and methods: Wistar albino rats were randomly divided into three experimental groups (six animals per group): Up and Down group - exposed to upward and downward oriented SMF, respectively, and Control group. After 50 days, the rats were sacrificed, and synaptosomes were isolated from the whole rat brain and used for testing the enzyme activities and oxidative stress parameters. Results: Chronic exposure to 1 mT SMF significantly increased ATPases, AChE activities, and malondialdehyde (MDA) level in both exposed groups, compared to control values. The significant decrease in synaptosomal catalase activity (1.48 ± 0.17 U/mg protein) induced by exposure to the downward oriented field, compared to those obtained for Control group (2.60 ± 0.29 U/mg protein), and Up group (2.72 ± 0.21 U/mg protein). Conclusions: It could be concluded that chronic exposure to differently oriented SMF increases ATPases and AChE activities in rat synaptosomes. Since brain ATPases and AChE have important roles in the pathogenesis of several neurological diseases, SMF influence on the activity of these enzymes may have potential therapeutic importance. © 2018, Copyright © 2018 Taylor & Francis Group, LLC.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175081/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172023/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Radiation Biology
dc.subjectStatic magnetic fielden
dc.subjectATPasesen
dc.subjectacetylcholinesteraseen
dc.subjectmalondialdehydeen
dc.subjectcatalaseen
dc.subjecthydroperoxidasesen
dc.titleModulation of rat synaptosomal ATPases and acetylcholinesterase activities induced by chronic exposure to the static magnetic fielden
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractДјордјевић, Драго М; Тодоровић, Јасна; Бркић, Предраг; Ћирковић, Саша; Динчић, Марко; Крстић, Данијела З; Чоловић, Мирјана Б; Нешовић Остојић, Јелена; Ковачевић, Сањин; Де Лука, Силвио Р;
dc.rights.holder© 2018 Taylor & Francis Group, LLC
dc.citation.volume94
dc.citation.issue11
dc.citation.spage1062
dc.citation.epage1071
dc.identifier.wos000451598500013
dc.identifier.doi10.1080/09553002.2018.1518611
dc.identifier.pmid30238840
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85053534681


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