Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators
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Autori
Stokić, EditaRomani, Andrea
Ilinčić, Branislava
Kupusinac, Aleksandar
Stošić, Zoran
Isenović, Esma R.
Članak u časopisu (Objavljena verzija)
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© 2018 Bentham Science Publishers
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Prikaz svih podataka o dokumentuApstrakt
Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 +/- 4 years, 52% women) were recruited based on weight/adiposity parameters {[}i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators {[}insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) -0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH) D), vitamin D deficiency < ...50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH) D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg < 0.85 mmol/L), a negative linear coefficient was found between 25(OH) D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg >= 0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.
Ključne reči:
Obesity / micronutrients / chronic latent magnesium deficiency / vitamin D deficiency / cardiometabolic risk indicators / insulin resistanceIzvor:
Current Vascular Pharmacology, 2018, 16, 6, 610-617Finansiranje / projekti:
- Hormonska regulacija ekspresije i aktivnosti azot oksid sintaze i natrijum-kalijumove pumpe u eksperimentalnim modelima insulinske rezistencije, dijabetesa i kardiovaskularnih poremećaja (RS-MESTD-Basic Research (BR or ON)-173033)
- Reprezentacije logičkih struktura i formalnih jezika i njihove primene u računarstvu (RS-MESTD-Basic Research (BR or ON)-174026)
- Razvoj novih informaciono-komunikacionih tehnologija, korišćenjem naprednih matematičkih metoda, sa primenama u medicini, telekomunikacijama, energetici, zaštititi nacionalne baštine i obrazovanju (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-44006)
- Provincial Secretariat for Science and Technological Development of the Autonomous Province of Vojvodina (114-451-2856/2016)
DOI: 10.2174/1570161115666170821154841
ISSN: 1570-1611; 1875-6212
PubMed: 28828979
WoS: 000444234200012
Scopus: 2-s2.0-85039731695
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Institucija/grupa
VinčaTY - JOUR AU - Stokić, Edita AU - Romani, Andrea AU - Ilinčić, Branislava AU - Kupusinac, Aleksandar AU - Stošić, Zoran AU - Isenović, Esma R. PY - 2018 UR - http://www.eurekaselect.com/155079/article UR - https://vinar.vin.bg.ac.rs/handle/123456789/7951 AB - Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 +/- 4 years, 52% women) were recruited based on weight/adiposity parameters {[}i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators {[}insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) -0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH) D), vitamin D deficiency < 50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH) D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg < 0.85 mmol/L), a negative linear coefficient was found between 25(OH) D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg >= 0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators. T2 - Current Vascular Pharmacology T1 - Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators VL - 16 IS - 6 SP - 610 EP - 617 DO - 10.2174/1570161115666170821154841 ER -
@article{ author = "Stokić, Edita and Romani, Andrea and Ilinčić, Branislava and Kupusinac, Aleksandar and Stošić, Zoran and Isenović, Esma R.", year = "2018", abstract = "Background: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and Cardiovascular Disease (CVD). Objective: We examined the frequency of concomitant deficit of Magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. Methods: Non-diabetic middle aged adults (n = 80; mean age 36 +/- 4 years, 52% women) were recruited based on weight/adiposity parameters {[}i.e. Body Mass Index (BMI) and body fat percentage (FAT%)]. Cardiometabolic risk indicators {[}insulin resistance (Homeostatic Model Assessment for Insulin Resistance (HOMA-IR)) and CVD risk (Framingham risk score for predicting 10-year CVD)], Mg status (i.e. total serum Mg concentration (TMg), Chronic Latent Mg Deficiency (CLMD) -0.75-0.85 mmol/L), vitamin D status (i.e. serum concentration of 25-hydroxyvitamin D (25(OH) D), vitamin D deficiency < 50 nmol/l) were assessed. Results: Among obese subjects 36% presented a combination of vitamin D deficiency and CLMD. In all studied patients, 25(OH) D and TMg levels both, individually and combined, showed a negative linear correlation with HOMA-IR and CVD risk. In subjects with CLMD (TMg < 0.85 mmol/L), a negative linear coefficient was found between 25(OH) D and, HOMA-IR and CVD risk, compared with subjects with normal TMg status (TMg >= 0.85 mmol/L). Conclusion: CLMD and vitamin D deficiency may commonly be present in obese non-diabetic subjects. Individually and combined, both deficiencies predispose non-diabetic patients to increased risk of cardiometabolic diseases. Maintaining normal Mg status may improve the beneficial effects of vitamin D on cardiometabolic risk indicators.", journal = "Current Vascular Pharmacology", title = "Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators", volume = "16", number = "6", pages = "610-617", doi = "10.2174/1570161115666170821154841" }
Stokić, E., Romani, A., Ilinčić, B., Kupusinac, A., Stošić, Z.,& Isenović, E. R.. (2018). Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators. in Current Vascular Pharmacology, 16(6), 610-617. https://doi.org/10.2174/1570161115666170821154841
Stokić E, Romani A, Ilinčić B, Kupusinac A, Stošić Z, Isenović ER. Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators. in Current Vascular Pharmacology. 2018;16(6):610-617. doi:10.2174/1570161115666170821154841 .
Stokić, Edita, Romani, Andrea, Ilinčić, Branislava, Kupusinac, Aleksandar, Stošić, Zoran, Isenović, Esma R., "Chronic Latent Magnesium Deficiency in Obesity Decreases Positive Effects of Vitamin D on Cardiometabolic Risk Indicators" in Current Vascular Pharmacology, 16, no. 6 (2018):610-617, https://doi.org/10.2174/1570161115666170821154841 . .