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Proteomic characterization of hippocampus of chronically socially isolated rats treated with fluoxetine: Depression-like behaviour and fluoxetine mechanism of action
dc.creator | Perić, Ivana | |
dc.creator | Costina, Victor | |
dc.creator | Stanisavljević, Andrijana | |
dc.creator | Findeisen, Peter | |
dc.creator | Filipović, Dragana | |
dc.date.accessioned | 2018-11-01T11:50:06Z | |
dc.date.available | 2018-11-01T11:50:06Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0028-3908 | |
dc.identifier.issn | 1873-7064 | |
dc.identifier.uri | https://linkinghub.elsevier.com/retrieve/pii/S0028390818301461 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/7913 | |
dc.description.abstract | Due to the severity of depressive symptoms, there remains a necessity in defining the underlying mechanisms of depression and the precise actions of antidepressants in alleviating these symptoms. Proteomics is a powerful and promising tool for discovering novel pathways of cellular responses to disease and treatment. As chronic social isolation (CSIS) is a valuable animal model for studying depression, we performed a comparative subproteomic study of rat hippocampus to explore the effect of six weeks of CSIS and the therapeutic effect of chronic fluoxetine (Flx) treatment (last three weeks of CSIS; 15 mg/kg/day). Behaviorally, Flx treatment normalized the decreased sucrose preference and increased marble burying results resulting from CSIS, indicative of a FLX-induced attenuation of both anhedonia and anxiety. An analysis of cytosolic and nonsynaptic mitochondrial subproteome patterns revealed that CSIS resulted in down-regulation of proteins involved in mitochondrial transport and energy processes, primarily tricarboxylic acid (TCA) cycle and oxidative phosphorylation. Chronic Flx treatment resulted in an up-regulation of CSIS-altered proteins and additional expression of other transporter and energy-involved proteins. Immunohistochemical analysis revealed hippocampal subregion-specific effects of CSIS and/or Flx treatment on selective protein expressions. (C) 2018 Elsevier Ltd. All rights reserved. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173044/RS// | |
dc.rights | restrictedAccess | |
dc.source | Neuropharmacology | |
dc.subject | Fluoxetine | en |
dc.subject | Depressive disorder | en |
dc.subject | Hippocampus | en |
dc.subject | Quantitative proteomics | en |
dc.subject | Protein interactomics | en |
dc.title | Proteomic characterization of hippocampus of chronically socially isolated rats treated with fluoxetine: Depression-like behaviour and fluoxetine mechanism of action | en |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Цостина, Вицтор; Филиповић, Драгана; Станисављевић, Aндријана; Перић, Ивана; Финдеисен, Петер; | |
dc.rights.holder | © 2018 Elsevier Ltd | |
dc.citation.volume | 135 | |
dc.citation.spage | 268 | |
dc.citation.epage | 283 | |
dc.identifier.wos | 000436915600024 | |
dc.identifier.doi | 10.1016/j.neuropharm.2018.03.034 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 29596899 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85044504379 |
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