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dc.creatorČakar, Uroš
dc.creatorGrozdanić, Nađa
dc.creatorPetrović, Aleksandar V.
dc.creatorPejin, Boris
dc.creatorNastasijević, Branislav J.
dc.creatorMarković, Bojan D.
dc.creatorĐorđević, Brižita
dc.date.accessioned2018-10-17T08:01:14Z
dc.date.available2018-10-17T08:01:14Z
dc.date.issued2018
dc.identifier.issn1389-2010 (print)
dc.identifier.issn1873-4316 (electronic)
dc.identifier.urihttp://www.eurekaselect.com/161153/article
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7860
dc.description.abstractBACKGROUND: Fruit wines are well known for their profound health-promoting properties including both enzyme activations and inhibitions. They may act preventive in regard to diabetes melitus and other chronic diseases. OBJECTIVES: Potential α-glucosidase inhibitory activity of fruit wines made from blueberry, black chokeberry, blackberry, raspberry and sour cherry was the subject of this study. METHOD: In order to increase the alcohol content due to enriched extraction of total phenolics, sugar was added in the fruit pomace of the half of the examined fruit wine samples. RESULTS: Compared with acarbose used as a positive control (IC50 = 73.78 µg/mL), all fruit wine samples exhibited higher α-glucosidase inhibitory activity. Indeed, blueberry wine samples stood out, both prepared with IC50 = 24.14 µg/mL, lyophilised extract yield 3.23% and without IC50 = 46.39 µg/mL, lyophilised extract yield 2.89% and with addition of sugar before fermentation. Chlorogenic acid predominantly contributed to α-glucosidase inhibitory activity of the blueberry, black chokeberry and sour cherry wine samples. However, ellagic acid, a potent α-glucosidase inhibitor possessing a planar structure, only slightly affected the activity of the blueberry wine samples, due to the lower concentration. In addition to this, molecular docking study of chlorogenic acid pointed out the importance of binding energy (-8.5 kcal/mol) for the inhibition of the enzyme. CONCLUSION: In summary, fruit wines made from blueberry should be primarily taken into consideration as a medicinal food targeting diabetes mellitus type 2 in the early stage, if additional studies would confirm their therapeutic potential for the control of postprandial hyperglycemia. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS//
dc.rightsrestrictedAccess
dc.sourceCurrent Pharmaceutical Biotechnology
dc.subjectfruit winesen
dc.subjectblueberryen
dc.subjectalpha-glucosidase inhibitory activityen
dc.subjectchlorogenic aciden
dc.subjectmolecular dockingen
dc.subjectmedicinal fooden
dc.titleFruit Wines Inhibitory Activity Against α-Glucosidaseen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractМарковић, Бојан Д.; Чакар, Урош; Настасијевић, Бранислав Ј.; Ђорђевић, Брижита; Петровић, Aлександар В.; Пејин, Борис; Грозданић, Нађа;
dc.rights.holder© Bentham Science Publishers
dc.citation.volume18
dc.citation.issue15
dc.citation.spage1264
dc.citation.epage1272
dc.identifier.wos000431242000005
dc.identifier.doi10.2174/1389201019666180410112439
dc.identifier.pmid29637856
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85052706990


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