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dc.creatorSatarić, Miljko V.
dc.creatorSekulić, Dalibor L.
dc.creatorSatarić, Bogdan M.
dc.creatorZdravković, Slobodan
dc.date.accessioned2018-03-01T16:28:31Z
dc.date.available2018-03-01T16:28:31Z
dc.date.issued2015
dc.identifier.issn0079-6107 (print)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/782
dc.description.abstractThis paper aims to provide an overview of the polyelectrolyte model and the current understanding of the creation and propagation of localized pulses of positive ions flowing along cellular microtubules. In that context, Ca2+ ions may move freely on the surface of microtubule along the protofilament axis, thus leading to signal transport. Special emphasis in this paper is placed on the possible role of this mechanism in the function of microtubule based kinocilium, a component of vestibular hair cells of the inner ear. We discuss how localized pulses of Ca2+ ions play a crucial role in tuning the activity of dynein motors, which are involved in mechano sensitivity of the kinocilium. A prevailing notion holds that the concentration of Ca2+ ions around the microtubules within the kinocilium represents the control parameter for Hopf bifurcation. Therefore, a key feature of this mechanism is that the velocities of these Ca2+ pulses be sufficiently high to exert control at acoustic frequencies. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43008/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45010/RS//
dc.relationSerbian Academy of Sciences and Arts
dc.rightsrestrictedAccessen
dc.sourceProgress in Biophysics and Molecular Biologyen
dc.subjectMicrotubuleen
dc.subjectPolyelectrolyteen
dc.subjectCalcium ionsen
dc.subjectHair cellsen
dc.subjectNonlinear ionic pulseen
dc.titleRole of nonlinear localized Ca2+ pulses along microtubules in tuning the mechano-sensitivity of hair cellsen
dc.typereviewen
dcterms.abstractСатариц, Богдан М.; Здравковић Слободан; Секулиц, Далибор Л.; Сатариц, Миљко В.;
dc.citation.volume119
dc.citation.issue2
dc.citation.spage162
dc.citation.epage174
dc.identifier.wos000363352900005
dc.identifier.doi10.1016/j.pbiomolbio.2015.07.009
dc.citation.rankM23
dc.identifier.pmid26208473
dc.identifier.scopus2-s2.0-84943453631


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