UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations
Само за регистроване кориснике
2019
Аутори
Savić, JasminaPetrović, Sandra
Leskovac, Andreja
Lazarević-Pašti, Tamara
Nastasijević, Branislav J.
Tanović, Brankica B.
Gašić, Slavica M.
Vasić, Vesna M.
Чланак у часопису (Објављена верзија)
,
© 2018 Elsevier Ltd
Метаподаци
Приказ свих података о документуАпстракт
UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered wh...en processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd
Кључне речи:
acetylcholinesterase / chlorpyrifos / genotoxicity / oxidative stress / photodegradationИзвор:
Food Chemistry, 2019, 271, 469-478Финансирање / пројекти:
- Истраживања интеракција ензима са токсичним и фармаколошки активним молекулима (RS-MESTD-Basic Research (BR or ON)-172023)
URI
https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670https://vinar.vin.bg.ac.rs/handle/123456789/7821
Колекције
Институција/група
VinčaTY - JOUR AU - Savić, Jasmina AU - Petrović, Sandra AU - Leskovac, Andreja AU - Lazarević-Pašti, Tamara AU - Nastasijević, Branislav J. AU - Tanović, Brankica B. AU - Gašić, Slavica M. AU - Vasić, Vesna M. PY - 2019 UR - https://linkinghub.elsevier.com/retrieve/pii/S0308814618313670 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7821 AB - UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd T2 - Food Chemistry T1 - UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations VL - 271 SP - 469 EP - 478 DO - 10.1016/j.foodchem.2018.07.207 ER -
@article{ author = "Savić, Jasmina and Petrović, Sandra and Leskovac, Andreja and Lazarević-Pašti, Tamara and Nastasijević, Branislav J. and Tanović, Brankica B. and Gašić, Slavica M. and Vasić, Vesna M.", year = "2019", abstract = "UV-C irradiation is widely used in the food industry. However, the health effects from dietary exposure to the irradiated pesticide residues retained in foodstuffs are underestimated. In this study, technical chlorpyrifos (TCPF) and its oil in water (EW) and emulsifiable concentrate (EC) formulations were irradiated by UV-C, and their photodegradation products were subjected to toxicity assessment, including determination of acetylcholinesterase (AChE) activity, genotoxicity and oxidative stress using human blood cells as a model system. Toxicity studies were performed using the chlorpyrifos concentrations in the range of those proposed as the maximum residue levels in plant commodities. TCPF, EW and EC photodegradation products induced DNA damage and oxidative stress, and their genotoxicity did not decrease as a function of irradiation time. Irradiated TCPF and EC are more potent AChE inhibitors than irradiated EW. Accordingly, the application of UV-C irradiation must be considered when processing the plants previously treated with chlorpyrifos formulations. © 2018 Elsevier Ltd", journal = "Food Chemistry", title = "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations", volume = "271", pages = "469-478", doi = "10.1016/j.foodchem.2018.07.207" }
Savić, J., Petrović, S., Leskovac, A., Lazarević-Pašti, T., Nastasijević, B. J., Tanović, B. B., Gašić, S. M.,& Vasić, V. M.. (2019). UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry, 271, 469-478. https://doi.org/10.1016/j.foodchem.2018.07.207
Savić J, Petrović S, Leskovac A, Lazarević-Pašti T, Nastasijević BJ, Tanović BB, Gašić SM, Vasić VM. UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations. in Food Chemistry. 2019;271:469-478. doi:10.1016/j.foodchem.2018.07.207 .
Savić, Jasmina, Petrović, Sandra, Leskovac, Andreja, Lazarević-Pašti, Tamara, Nastasijević, Branislav J., Tanović, Brankica B., Gašić, Slavica M., Vasić, Vesna M., "UV-C light irradiation enhances toxic effects of chlorpyrifos and its formulations" in Food Chemistry, 271 (2019):469-478, https://doi.org/10.1016/j.foodchem.2018.07.207 . .