Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents
Само за регистроване кориснике
2018
Аутори
Stanojković, Tatjana P.Marković, Violeta
Matić, Ivana Z.
Mladenović, Milan P.
Petrović, Nina
Krivokuća, Ana M.
Petković, Miloš R.
Joksović, Milan D.
Чланак у часопису (Објављена верзија)
,
© 2018 Elsevier Ltd
Метаподаци
Приказ свих података о документуАпстракт
A series of 23 novel anthraquinone-chalcone hybrids containing amide function was synthesized and structurally characterized. Sixteen compounds exerted strong cytotoxic activities against K562, Jurkat and HL-60 leukemia cell lines and significantly lower cytotoxic effects against normal MRC-5 cells, indicating very high selectivity in their anticancer action. The compounds 6g, 6u and 6v activate apoptosis in K562 cells through the extrinsic and intrinsic apoptotic pathway. The compound 6e triggered apoptosis in K562 cells only through the extrinsic apoptotic pathway. Treatment of K562 cells with each of these four compounds caused decrease in the expression levels of MMP2, MMP9, and VEGF, suggesting their anti-invasive, antimetastatic and antiangiogenic properties. The compounds 6g and 6v downregulated expression levels of miR-155 in K562 cells, while compounds 6e and 6u upregulated miR-155 levels in treated cells, in comparison with control cells. The structure-based 3-D QSAR models f...or 6f, 6e, 6i and 6l describe pro-apoptotic activity against caspase-3. © 2018 Elsevier Ltd
Кључне речи:
anthraquinone-chalcone / leukemia / gene expression / miR-155 / 3-D QSARИзвор:
Bioorganic and Medicinal Chemistry Letters, 2018, 28, 15, 2593-2598Финансирање / пројекти:
- Синтеза, моделовање, физичко-хемијске и биолошке особине органских једињења и одговарајућих комплекса метала (RS-172016)
- Модификатори биолошког одговора у физиолошким и патолошким стањима (RS-175011)
DOI: 10.1016/j.bmcl.2018.06.048
ISSN: 0960-894X; 1464-3405
PubMed: 29970309
WoS: 000440568900003
Scopus: 2-s2.0-85049322460
URI
https://linkinghub.elsevier.com/retrieve/pii/S0960894X18305493https://vinar.vin.bg.ac.rs/handle/123456789/7815
Колекције
Институција/група
VinčaTY - JOUR AU - Stanojković, Tatjana P. AU - Marković, Violeta AU - Matić, Ivana Z. AU - Mladenović, Milan P. AU - Petrović, Nina AU - Krivokuća, Ana M. AU - Petković, Miloš R. AU - Joksović, Milan D. PY - 2018 UR - https://linkinghub.elsevier.com/retrieve/pii/S0960894X18305493 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7815 AB - A series of 23 novel anthraquinone-chalcone hybrids containing amide function was synthesized and structurally characterized. Sixteen compounds exerted strong cytotoxic activities against K562, Jurkat and HL-60 leukemia cell lines and significantly lower cytotoxic effects against normal MRC-5 cells, indicating very high selectivity in their anticancer action. The compounds 6g, 6u and 6v activate apoptosis in K562 cells through the extrinsic and intrinsic apoptotic pathway. The compound 6e triggered apoptosis in K562 cells only through the extrinsic apoptotic pathway. Treatment of K562 cells with each of these four compounds caused decrease in the expression levels of MMP2, MMP9, and VEGF, suggesting their anti-invasive, antimetastatic and antiangiogenic properties. The compounds 6g and 6v downregulated expression levels of miR-155 in K562 cells, while compounds 6e and 6u upregulated miR-155 levels in treated cells, in comparison with control cells. The structure-based 3-D QSAR models for 6f, 6e, 6i and 6l describe pro-apoptotic activity against caspase-3. © 2018 Elsevier Ltd T2 - Bioorganic and Medicinal Chemistry Letters T1 - Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents VL - 28 IS - 15 SP - 2593 EP - 2598 DO - 10.1016/j.bmcl.2018.06.048 ER -
@article{ author = "Stanojković, Tatjana P. and Marković, Violeta and Matić, Ivana Z. and Mladenović, Milan P. and Petrović, Nina and Krivokuća, Ana M. and Petković, Miloš R. and Joksović, Milan D.", year = "2018", abstract = "A series of 23 novel anthraquinone-chalcone hybrids containing amide function was synthesized and structurally characterized. Sixteen compounds exerted strong cytotoxic activities against K562, Jurkat and HL-60 leukemia cell lines and significantly lower cytotoxic effects against normal MRC-5 cells, indicating very high selectivity in their anticancer action. The compounds 6g, 6u and 6v activate apoptosis in K562 cells through the extrinsic and intrinsic apoptotic pathway. The compound 6e triggered apoptosis in K562 cells only through the extrinsic apoptotic pathway. Treatment of K562 cells with each of these four compounds caused decrease in the expression levels of MMP2, MMP9, and VEGF, suggesting their anti-invasive, antimetastatic and antiangiogenic properties. The compounds 6g and 6v downregulated expression levels of miR-155 in K562 cells, while compounds 6e and 6u upregulated miR-155 levels in treated cells, in comparison with control cells. The structure-based 3-D QSAR models for 6f, 6e, 6i and 6l describe pro-apoptotic activity against caspase-3. © 2018 Elsevier Ltd", journal = "Bioorganic and Medicinal Chemistry Letters", title = "Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents", volume = "28", number = "15", pages = "2593-2598", doi = "10.1016/j.bmcl.2018.06.048" }
Stanojković, T. P., Marković, V., Matić, I. Z., Mladenović, M. P., Petrović, N., Krivokuća, A. M., Petković, M. R.,& Joksović, M. D.. (2018). Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents. in Bioorganic and Medicinal Chemistry Letters, 28(15), 2593-2598. https://doi.org/10.1016/j.bmcl.2018.06.048
Stanojković TP, Marković V, Matić IZ, Mladenović MP, Petrović N, Krivokuća AM, Petković MR, Joksović MD. Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents. in Bioorganic and Medicinal Chemistry Letters. 2018;28(15):2593-2598. doi:10.1016/j.bmcl.2018.06.048 .
Stanojković, Tatjana P., Marković, Violeta, Matić, Ivana Z., Mladenović, Milan P., Petrović, Nina, Krivokuća, Ana M., Petković, Miloš R., Joksović, Milan D., "Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents" in Bioorganic and Medicinal Chemistry Letters, 28, no. 15 (2018):2593-2598, https://doi.org/10.1016/j.bmcl.2018.06.048 . .