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dc.creatorZmejkoski, Danica
dc.creatorSpasojević, Dragica
dc.creatorOrlovska, Irina V.
dc.creatorKozyrovska, Natalia O.
dc.creatorSoković, Marina
dc.creatorGlamočlija, Jasmina
dc.creatorDmitrović, Svetlana
dc.creatorMatović, Branko
dc.creatorTasić, Nikola B.
dc.creatorMaksimović, Vuk M.
dc.creatorSosnin, Mikhail
dc.creatorRadotić, Ksenija
dc.date.accessioned2018-07-19T09:57:52Z
dc.date.available2018-07-19T09:57:52Z
dc.date.issued2018
dc.identifier.issn0141-8130 (print)
dc.identifier.urihttps://linkinghub.elsevier.com/retrieve/pii/S0141813018320919
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7769
dc.description.abstractLignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45012/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173017/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173032/RS//
dc.relationNational Academy of Sciences of Ukraine (47/2015-2016)
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Biological Macromolecules
dc.subjectantimicrobial activityen
dc.subjectbacterial celluloseen
dc.subjectlignin model polymeren
dc.titleBacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healingen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractРадотић, Ксенија; Змејкоски, Даница; Дмитровић, Светлана; Матовић, Бранко; Спасојевић, Драгица; Орловска, Ирина; Козyровска, Наталиа; Соковић, Марина; Гламочлија, Јасмина; Тасић, Никола Б.; Максимовић, Вук М.; Соснин, Микхаил;
dc.rights.holder© 2018 Elsevier B.V.
dc.citation.volume118
dc.citation.spage494
dc.citation.epage503
dc.identifier.wos000445170200057
dc.identifier.doi10.1016/j.ijbiomac.2018.06.067
dc.identifier.pmid29909035
dc.type.versionacceptedVersion
dc.identifier.scopus2-s2.0-85049108073


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