Role of Ectonucleotidases in the Synapse Formation During Brain Development: Physiological and Pathological Implications
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Extracellular adenine nucleotides and nucleosides, such as ATP and adenosine, are among the most recently identified and least investigated diffusible signaling factors that contribute to the structural and functional remodeling of the brain, both during embryonic and postnatal development. Their levels in the extracellular milieu are tightly controlled by various ectonucleotidases: ectonucleotide pyrophosphatase/phosphodiesterases (E-NPP), alkaline phosphatases (AP), ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) and ecto-5'-nucleotidase (eN). During central nervous system development and in adulthood all ectonucleotidases have diverse expression pattern, cell specific localization and function. Formation, maturation, and refinement of synaptic contacts are influenced by neurotransmitters and neuromodulators, and control of extracellular adenine nucleotide levels by ectonucleotidases are important for understanding the role of purinergic signaling in developing tiss...ues and potential targets in developmental disorders such as autism.
Извор:
Current Neuropharmacology, 2019, 17, 1, 84-98
DOI: 10.2174/1570159X15666170518151541
ISSN: 1875-6190
PubMed: 28521702
WoS: 000458581600008
Scopus: 2-s2.0-85058927079
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http://www.eurekaselect.com/node/152565/articlehttps://vinar.vin.bg.ac.rs/handle/123456789/7758
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VinčaTY - JOUR AU - Grković, Ivana AU - Drakulić, Dunja R. AU - Martinović, Jelena AU - Mitrović, Nataša Lj. PY - 2019 UR - http://www.eurekaselect.com/node/152565/article UR - https://vinar.vin.bg.ac.rs/handle/123456789/7758 AB - Extracellular adenine nucleotides and nucleosides, such as ATP and adenosine, are among the most recently identified and least investigated diffusible signaling factors that contribute to the structural and functional remodeling of the brain, both during embryonic and postnatal development. Their levels in the extracellular milieu are tightly controlled by various ectonucleotidases: ectonucleotide pyrophosphatase/phosphodiesterases (E-NPP), alkaline phosphatases (AP), ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) and ecto-5'-nucleotidase (eN). During central nervous system development and in adulthood all ectonucleotidases have diverse expression pattern, cell specific localization and function. Formation, maturation, and refinement of synaptic contacts are influenced by neurotransmitters and neuromodulators, and control of extracellular adenine nucleotide levels by ectonucleotidases are important for understanding the role of purinergic signaling in developing tissues and potential targets in developmental disorders such as autism. T2 - Current Neuropharmacology T1 - Role of Ectonucleotidases in the Synapse Formation During Brain Development: Physiological and Pathological Implications VL - 17 IS - 1 SP - 84 EP - 98 DO - 10.2174/1570159X15666170518151541 ER -
@article{ author = "Grković, Ivana and Drakulić, Dunja R. and Martinović, Jelena and Mitrović, Nataša Lj.", year = "2019", abstract = "Extracellular adenine nucleotides and nucleosides, such as ATP and adenosine, are among the most recently identified and least investigated diffusible signaling factors that contribute to the structural and functional remodeling of the brain, both during embryonic and postnatal development. Their levels in the extracellular milieu are tightly controlled by various ectonucleotidases: ectonucleotide pyrophosphatase/phosphodiesterases (E-NPP), alkaline phosphatases (AP), ectonucleoside triphosphate diphosphohydrolases (E-NTPDases) and ecto-5'-nucleotidase (eN). During central nervous system development and in adulthood all ectonucleotidases have diverse expression pattern, cell specific localization and function. Formation, maturation, and refinement of synaptic contacts are influenced by neurotransmitters and neuromodulators, and control of extracellular adenine nucleotide levels by ectonucleotidases are important for understanding the role of purinergic signaling in developing tissues and potential targets in developmental disorders such as autism.", journal = "Current Neuropharmacology", title = "Role of Ectonucleotidases in the Synapse Formation During Brain Development: Physiological and Pathological Implications", volume = "17", number = "1", pages = "84-98", doi = "10.2174/1570159X15666170518151541" }
Grković, I., Drakulić, D. R., Martinović, J.,& Mitrović, N. Lj.. (2019). Role of Ectonucleotidases in the Synapse Formation During Brain Development: Physiological and Pathological Implications. in Current Neuropharmacology, 17(1), 84-98. https://doi.org/10.2174/1570159X15666170518151541
Grković I, Drakulić DR, Martinović J, Mitrović NL. Role of Ectonucleotidases in the Synapse Formation During Brain Development: Physiological and Pathological Implications. in Current Neuropharmacology. 2019;17(1):84-98. doi:10.2174/1570159X15666170518151541 .
Grković, Ivana, Drakulić, Dunja R., Martinović, Jelena, Mitrović, Nataša Lj., "Role of Ectonucleotidases in the Synapse Formation During Brain Development: Physiological and Pathological Implications" in Current Neuropharmacology, 17, no. 1 (2019):84-98, https://doi.org/10.2174/1570159X15666170518151541 . .