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dc.creatorSavić, Danka A.
dc.creatorKnežević, Goran
dc.creatorMatić, Gordana
dc.creatorDamjanović, Svetozar S.
dc.date.accessioned2018-07-12T08:20:45Z
dc.date.available2018-07-12T08:20:45Z
dc.date.issued2018
dc.identifier.issn0306-4530 (print)
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S030645301830088X
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7745
dc.description.abstractBackground Research results on dehydroepiandrosterone sulfate ester (DHEAS) in post-traumatic stress disorder (PTSD) are inconsistent. We hypothesized that personality traits could be the confounders of DHEAS levels and disease symptoms, which could in part explain the discrepancy in findings. Method: This study was a part of a broader project in which simultaneous psychological and biological in-vestigations were carried out in hospital conditions. 380 male subjects were categorized in four groups: A) current PTSD (n = 132), B) lifetime PTSD (n = 66), C) trauma controls (n = 101), and D) healthy controls (n = 81), matched by age. Results: The level of DHEAS is significantly lower in the current PTSD group than in trauma controls. All groups significantly differ in personality traits Disintegration and Neuroticism (current PTSD group having the highest scores). DHEAS is related to both PTSD and depressive symptoms; however, Structural Equation Model (SEM) shows that the relations are indirect, realized via their confounder-personality trait Disintegration. Conclusions: According to our project results, DHEAS is the second putative biomarker for trauma-related dis-orders that fails to fulfil this expectation. It appears to be more directly related to personality than to the disease symptoms (the first one being basal cortisol). Our data promote personality as a biologically based construct with seemingly important role in understanding the mental health status.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/179018/RS//
dc.relationEuropean Commission (INCO-CT-2004-509213)
dc.rightsrestrictedAccess
dc.sourcePsychoneuroendocrinology
dc.subjectDHEASen
dc.subjectpersonality traitsen
dc.subjectpost-traumatic stress disorderen
dc.subjectdepressionen
dc.subjectstructure equation modelen
dc.titlePTSD and depressive symptoms are linked to DHEAS via personalityen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСавић, Данка A.; Матић, Гордана; Дамјановић, Светозар С.; Кнежевић, Горан;
dc.rights.holder© 2018 Elsevier Ltd.
dc.citation.volume92
dc.citation.spage29
dc.citation.epage33
dc.identifier.wos000433266200004
dc.identifier.doi10.1016/j.psyneuen.2018.03.017
dc.identifier.pmid29621722
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85044739815


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