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dc.creatorSpirou, Spiridon
dc.creatorCosta Lima, Sofia
dc.creatorBouziotis, Penelope
dc.creatorVranješ-Đurić, Sanja
dc.creatorEfthimiadou, Eleni
dc.creatorLaurenzana, Anna
dc.creatorBarbosa, Ana
dc.creatorGarcia-Alonso, Ignacio
dc.creatorJones, Carlton
dc.creatorJanković, Drina
dc.creatorGobbo, Oliviero
dc.date.accessioned2018-07-04T08:22:06Z
dc.date.available2018-07-04T08:22:06Z
dc.date.issued2018
dc.identifier.issn2079-4991 (print)
dc.identifier.urihttp://www.mdpi.com/2079-4991/8/5/306
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7707
dc.description.abstractMagnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.en
dc.relationCOST (European Cooperation in Science and Technology) (RADIOMAG (TD1402))
dc.rightsopenAccess
dc.sourceNanomaterials
dc.subjectanimal modelsen
dc.subjectbiodistributionen
dc.subjectin vitro assaysen
dc.subjectin vivo evaluationen
dc.subjectmagnetic nanoparticlesen
dc.subjectpharmacokineticsen
dc.titleRecommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapyen
dc.typearticleen
dc.rights.licenseBY
dcterms.abstractГоббо, Оливиеро; Боузиотис, Пенелопе; Спироу, Спиридон; Цоста Лима, Софиа; Врањеш-Дјурић, Сања; Ефтхимиадоу, Елени; Лаурензана, Aнна; Барбоса, Aна; Гарциа-Aлонсо, Игнацио; Јонес, Царлтон; Јанковиц, Дрина;
dc.rights.holder© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
dc.citation.volume8
dc.citation.issue5
dc.citation.spage306
dc.identifier.wos000435198300037
dc.identifier.doi10.3390/nano8050306
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85047646816
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/10146/Spirou-2018-Recommendations-for-in-vitro-and-in.pdf


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