Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy
Autori
Spirou, SpiridonCosta Lima, Sofia
Bouziotis, Penelope
Vranješ-Đurić, Sanja
Efthimiadou, Eleni
Laurenzana, Anna
Barbosa, Ana
Garcia-Alonso, Ignacio
Jones, Carlton
Janković, Drina
Gobbo, Oliviero
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and... characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.
Ključne reči:
animal models / biodistribution / in vitro assays / in vivo evaluation / magnetic nanoparticles / pharmacokineticsIzvor:
Nanomaterials, 2018, 8, 5, 306-Finansiranje / projekti:
- COST (European Cooperation in Science and Technology) (RADIOMAG (TD1402))
DOI: 10.3390/nano8050306
ISSN: 2079-4991
WoS: 000435198300037
Scopus: 2-s2.0-85047646816
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Spirou, Spiridon AU - Costa Lima, Sofia AU - Bouziotis, Penelope AU - Vranješ-Đurić, Sanja AU - Efthimiadou, Eleni AU - Laurenzana, Anna AU - Barbosa, Ana AU - Garcia-Alonso, Ignacio AU - Jones, Carlton AU - Janković, Drina AU - Gobbo, Oliviero PY - 2018 UR - http://www.mdpi.com/2079-4991/8/5/306 UR - https://vinar.vin.bg.ac.rs/handle/123456789/7707 AB - Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work. T2 - Nanomaterials T1 - Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy VL - 8 IS - 5 SP - 306 DO - 10.3390/nano8050306 ER -
@article{ author = "Spirou, Spiridon and Costa Lima, Sofia and Bouziotis, Penelope and Vranješ-Đurić, Sanja and Efthimiadou, Eleni and Laurenzana, Anna and Barbosa, Ana and Garcia-Alonso, Ignacio and Jones, Carlton and Janković, Drina and Gobbo, Oliviero", year = "2018", abstract = "Magnetic nanoparticle (MNP)-mediated hyperthermia (MH) coupled with radiation therapy (RT) is a novel approach that has the potential to overcome various practical difficulties encountered in cancer treatment. In this work, we present recommendations for the in vitro and in vivo testing and application of the two treatment techniques. These recommendations were developed by the members of Working Group 3 of COST Action TD 1402: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (“Radiomag”). The purpose of the recommendations is not to provide definitive answers and directions but, rather, to outline those tests and considerations that a researcher must address in order to perform in vitro and in vivo studies. The recommendations are divided into 5 parts: (a) in vitro evaluation of MNPs; (b) in vitro evaluation of MNP-cell interactions; (c) in vivo evaluation of the MNPs; (d) MH combined with RT; and (e) pharmacokinetic studies of MNPs. Synthesis and characterization of the MNPs, as well as RT protocols, are beyond the scope of this work.", journal = "Nanomaterials", title = "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy", volume = "8", number = "5", pages = "306", doi = "10.3390/nano8050306" }
Spirou, S., Costa Lima, S., Bouziotis, P., Vranješ-Đurić, S., Efthimiadou, E., Laurenzana, A., Barbosa, A., Garcia-Alonso, I., Jones, C., Janković, D.,& Gobbo, O.. (2018). Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. in Nanomaterials, 8(5), 306. https://doi.org/10.3390/nano8050306
Spirou S, Costa Lima S, Bouziotis P, Vranješ-Đurić S, Efthimiadou E, Laurenzana A, Barbosa A, Garcia-Alonso I, Jones C, Janković D, Gobbo O. Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy. in Nanomaterials. 2018;8(5):306. doi:10.3390/nano8050306 .
Spirou, Spiridon, Costa Lima, Sofia, Bouziotis, Penelope, Vranješ-Đurić, Sanja, Efthimiadou, Eleni, Laurenzana, Anna, Barbosa, Ana, Garcia-Alonso, Ignacio, Jones, Carlton, Janković, Drina, Gobbo, Oliviero, "Recommendations for In Vitro and In Vivo Testing of Magnetic Nanoparticle Hyperthermia Combined with Radiation Therapy" in Nanomaterials, 8, no. 5 (2018):306, https://doi.org/10.3390/nano8050306 . .