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dc.creatorŠvorc, Lubomir
dc.creatorStrežova, Ivana
dc.creatorKianičkova, Kristina
dc.creatorStanković, Dalibor M.
dc.creatorOtrisal, Pavel
dc.creatorSamphao, Anchalee
dc.date.accessioned2018-07-02T10:14:34Z
dc.date.available2018-07-02T10:14:34Z
dc.date.issued2018
dc.identifier.issn1572-6657 (print)
dc.identifier.urihttps://linkinghub.elsevier.com/retrieve/pii/S1572665718303783
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/7698
dc.description.abstractHerein, an advanced electroanalytical approach for the determination of ibuprofen based on the use of a bare and electrochemically untreated boron-doped diamond electrode is presented. Cyclic voltammetric study revealed that the electrode reaction of the analyte was manifested by the presence of well-shaped irreversible and diffusion-driven oxidation peak at very high potential (+1.75 V vs. Ag/AgCl/3 mol L−1KCl reference electrode) in 1 mol L−1perchloric acid. After optimization of experimental conditions, the peak current of ibuprofen was proportionally linear from 9.49 × 10−7to 6.69 × 10−5mol L−1providing both differential pulse (DPV) and square-wave voltammetric (SWV) techniques, respectively. The elaborated electroanalytical protocol rendered low detection limits of 4.1 × 10−7and 9.3 × 10−7mol L−1in association with favourable intra-day repeatability (relative standard deviation of 3.6 and 4.6%) using DPV and SWV procedures, respectively. The effect of interfering compounds such as ascorbic acid, dopamine, caffeine, uric acid and glucose on the current response of ibuprofen was explored in details. The usefulness of the proposed approach was verified in the analysis of a variety of commercial brands of pharmaceuticals and spiked human urine samples with the significant range of recovery percentages (for pharmaceuticals: 99.8–107.5% and 99.8–105.0% by DPV and SWV, for urine: 95–107% and 97–103% by DPV and SWV). Taking these features into account, the developed protocol may be exploited as a novel, simple and efficient tool in drug quality control analysis and analysis of biological samples. In addition, a bare and electrochemically untreated boron-doped diamond electrode may be applied as a progressive electrochemical sensor and helpful alternative to previously utilized electrochemical platforms in this field.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172030/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/621375/EU//
dc.relationGrant Agency of the Slovak Republic (No. 1/0489/16)
dc.rightsrestrictedAccess
dc.sourceJournal of Electroanalytical Chemistry
dc.subjectBoron-doped diamond electrodeen
dc.subjectdifferential pulse voltammetryen
dc.subjectibuprofenen
dc.subjectpharmaceutical dosageen
dc.subjectsquare-wave voltammetryen
dc.titleAn advanced approach for electrochemical sensing of ibuprofen in pharmaceuticals and human urine samples using a bare boron-doped diamond electrodeen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСтрежова, Ивана; Кианичкова, Кристина; Шворц, Лубомир; Отрисал, Павел; Сампхао, Aнцхалее; Станковић, Далибор М.;
dc.rights.holder© 2018 Elsevier B.V.
dc.citation.volume822
dc.citation.spage144
dc.citation.epage152
dc.identifier.wos000438005300018
dc.identifier.doi10.1016/j.jelechem.2018.05.026
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85047245918


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